Effect of the expression level of diacylglycerol kinase gamma in paracancerous tissue on postoperative survival in patients with hepatocellular carcinoma / 临床肝胆病杂志

ObjectiveTo investigate the effect of the expression level of diacylglycerol kinase gamma (DGKγ) in paracancerous tissue on the postoperative prognosis of patients with hepatocellular carcinoma (HCC) and its clinical value. MethodsRelated clinical data were collected from 78 HCC patients who were admitted and underwent surgical resection from December 2008 to August 2012 in the Affiliated Cancer Hospital of Zhengzhou University. Quantitative real-time PCR was used to measure the mRNA expression level of DGKγ in paracancerous tissue, and then the 78 patients were divided into low expression group (DGKγ ＜0.086 2, LEP group) and high expression group (DGKγ ≥0.086 2, HEP group). Basic data and clinical features were compared between the two groups. The t-test and the Mann-Whitney U test were used for comparison of continuous data, and the chi-square test and the corrected chi-square test were used for comparison of categorical data. Univariate and multivariate Cox regression analyses were used to investigate independent influencing factors for survival and prognosis, and the Kaplan-Meier method was used to analyze the overall survival trends of all patients and the LEP and HEP groups in each subgroup of Barcelona Clinic Liver Cancer (BCLC) stages. ResultsThe multivariate Cox regression analysis showed that the expression level of DGKγ (HR=1.913，95%CI： 1.111-3.296，P=0.019), HBsAg (HR=2.645，95%CI：1.264-5.537，P=0.010), Alb (HR=0.952，95%CI：0.916-0.990，P=0.013), BCLC stage (HR=1.702，95%CI：1267-2.286，P＜0001) and tumor size (HR=1.083，95%CI：1.019-1.152，P=0011) were independent influencing factors for long-term survival of HCC patients； the LEP group had a significantly longer median survival time than the HEP group (45.0 months vs 22.9 months, P=0002 5). The stratified analysis showed that for BCLC stage A HCC, the LEP group had significantly better long-term survival than the HEP group (P=0.034 5); for BCLC stage B/C HCC, the LEP group had a longer median survival time than the HEP group (16.5 months vs 10.8 months), but there was no significant difference in short- and long-term survival between the two groups (P＞0.05). ConclusionThe expression level of DGKγ in paracancerous tissue may be a new index for predicting and evaluating the long-term survival risk of HCC patients after surgery and has certain value in clinical application.

Characterization of stabilized waste: Evaluation of pollution risk

This study relates to the characterization of stabilized waste. Various parameters such as granulometric distribution, percentage of mineral and organic matter were estimated to appreciate environmental hazard potential and possibility of metal leaching of the samples of waste from Grange site in France. From the results, it was shown that the granulometric distribution was variable. Therefore, a strong proportion of fines [44.6%] and medium [45.9%] was observed due to the age of waste that supports the degradation of a great quantity of organic matter. That was confirmed by the strong mineral matter rate [63.8%] obtained to determine the organic percentage of matter [36.2%]. The amount of heavy metals such as iron, nickel, copper, zinc, cadmium and lead was also studied. The results obtained were in a good agreement with the ones of the literature. Indeed, it appeared that iron, lead, copper, nickel and zinc are in relative strong proportion while cadmium was not very present. Iron represents 78% of the metals. From the leaching tests, it was shown that the heavy metals concentration were very weak. Moreover, the deposit of studied waste could be a potential source of organic pollution [COD = 150 Mg C/L on average] in the case of precipitation and flood

Wastewater dephosphorization using crude clays

The present work aims to establish the possibility of using local clays to treat wastewater. Thus, three clay samples extracted from two localities in the south of C"te d_Ivoire have been studied in their crude state. The qualitative physicochemical study that consisted in measurement of pH variation and argillaceous particles zeta potential showed that the Nieki-Agneby clay and the Beige Anyama clay presented disposal to uptake phosphate ions in solution at pH 5. For each clay, it is shown that the tension accompanying the sorption of a phosphate ion could be estimated to -5 mV. Differences in their composition and in the number of hydrating molecules of water were also accessible. The quantitative study performed with the Nieki-Agneby clay thereafter consisted following the sorption kinetic. The adsorption was found to reach the maximum after 5 h. of exchange, and almost 400 micro g phosphate ions in per gram of clay were fixed. Future studies will focus on the modification of these materials in order to increase their sorption capacity

[Genitourinary complications of pelvic trauma]

Objective: To analyse the epidemiological features, diagnostic criteria and therapeutic aspects of 41 genitourinary lesions due to pelvic fracture

Patients and Methods : This is a retrospective analysis of 41 consecutive cases of pelvic trauma associated with urinary or genital complications seen over a 5-year period at the University Hospital of Treichville, Abidjan, Côte d'Ivoire. The patients had a mean age of 27.8 years [range: 14 - 48 years] with a male-to-female ratio of 9.25 to 1

Results: Traffic accidents were the prevailing cause of trauma accounting for 75.6%. The commonest type of fracture was anterior arc fracture encountered in 26.9% of the patients. The commonest presenting symptoms were chronic urinary retention [16.7%], bleeding per urethram [10.4%] and hematuria [29.1%]. Urethral lesions were encountered in 50%, bladder lesions in 38.5%, lesions of the external genitalia in 9.6% and prostatic lesions in 1.9% of patients. In the majority of the patients [51.2%] urethral repair was attempted by the spatulated anastomotic technique. In cases of disruption of the membranous urethra, urethral repair was delayed by 3 months. The functional results of treatment were good in 66%, while satisfactory erectile function could be achieved in 73% of the patients. Mortality was 4.9%

Conclusion: The prognosis of patients with pelvic trauma can be improved by a fast diagnosis and by resorting to a multidisciplinary team taking care of the multiple visceral injuries in association with the urogenital ones