In vitro antioxidant activity of roots of Thespesia lampas Dalz and Gibs

The free radical scavenging potential of roots of Thespesia lampas Dalz and Gibs was studied by different antioxidant models. Free radicals are implicated for more than 80 diseases including Diabetes mellitus, arthritis, cancer, ageing etc. In the treatment of theses diseases, antioxidant therapy has gained an utmost importance. Current research is directed towards finding naturally occurring antioxidant of plant origin. In Indian system of medicine, Thespesia lampas is an important medicinal plant and its root juice has been used in various ailments and as health tonic. To understand the mechanisms of pharmacological actions, the in vitro antioxidant activity of aqueous extract of Thespesia lampas was investigated for the activity of scavenging superoxide anion radicals, nitric oxide radical and lipid peroxidation assay. In all the testing, a significant correlation existed between concentrations of the extract and percentage inhibition of free radicals, metal chelating, reducing power or inhibition of lipid peroxidation. These results clearly indicate that Thespesia lampas is effective against free radical mediated diseases

Anti-inflammatory activity of aerial parts of tephrosia purpurea linn.

The crude extracts of aerial parts of Tephrosia purpurea Linn. was tested for anti-inflammatory activities. The effect of ethanolic and aqueous extracts were investigated in rats to evaluate the anti-inflammatory activity. Carrageenan-induced and histamine-induced rat paw oedema methods were employed to test anti-inflammatory activity. The ethanolic and aqueous extracts [250 mg/kg] showed the inhibition of carrageenan-induced rats paw oedema and also found to be effective in histamine-induced method. The results indicate that both ethanolic and aqueous extracts showed significant [P<0.001] anti-inflammatory activity when compared to control