RESUMO
Background: This study was conducted to reveal that whether i.v. injection of oleuropein, the most potent polyphenolic antioxidant in olive leaf, has any effect on the magnitude of reperfusion arrhythmia in anesthetized rats or not
Methods: Eighty male Wistar rats were divided into 8 groups of 10 each: groups 1 and 5 were assigned as the prophylac c and treatment control groups, groups 2 and 6 as the prophylac c and treatment groups with lidocaine [10 mg/kg], groups 3 and 4 as the prophylac c groups with 10 and 50mg/kg oleuropein [i.v.], and groups 7 and 8 as the treatment groups with 10 and 50 mg/kg oleuropein [i.v.], respectively. Reperfusion injury was induced by 5-min regional ischemia and 15-min reperfusion of left anterior descending coronary artery. Heart rate, blood pressure, and electrocardiogram were monitored throughout the procedure
Results: blood pressure was significantly decreased by infusion of 50 mg/kg oleuropein in groups 4 and 8, but unlike the lidocaine as a standard anti-arrhythmic drug in groups 2 and 5 had not significant effect on heart rate. The onset of arrhythmia in groups received oleuropein [groups 3, 4, 7, and 8] was significantly delayed. The mortality rate due to irreversible ventricular fibrillation was also significantly reduced in groups 3, 4, 7, and 8. The effect of lidocaine in groups 2 and 5 was more potent than that in oleuropein group
Conclusion: These findings indicate that i.v. injection of oleuropein possibly through its antioxidant activity reduces the magnitude of reperfusion-induced arrhythmia
RESUMO
Diagnosis of coronary artery disease [CAD] in early stages is vital in decreasing mortality by reducing the risk factors. The aim of this study was to investigate the association between erectile dysfunction [ED] and CAD. A total of 200 patients were divided into four groups according to their angiography Group 1 [G1, n = 59]: patients with one-vessel disease [1-VD]; Group 2 [G2, n = 40]: patients with two-vessel disease [2-VD]; Group 3 [G3, n = 50]: patients with three-vessel disease [3-VD]; and controls [C, n = 51] without any coronary disease. The International Index of Erectile Function [IIEF] was completed for all the patients to assess their sexual function and ED in the last 6 months. Mean age of the participants was 57.69 +/- 12.466 years. The prevalence of ED in the CAD patients was significantly higher than that of the controls [75.16% vs. 60.8%; p value = 0.041]. There was a significant direct correlation between the number of involved vessels in the CAD patients and ED severity [r: 0.183; p value = 0.010], and the ED rate increased with age. In conclusion, ED severity correlated with the number of involved vessels documented by coronary angiography. Consequently, ED may be considered a possible marker for the development of atherosclerosis and CAD