RESUMO
Recent studies show that, Inflammation plays an important role in the initiation and progression of atherosclerosis and in the pathogenesis of acute cardiovascular events. There is a possible association between ventricular dysfunction following acute myocardial infarction and high Sensitivity C-reactive protein [HS-CRP] and uric acid. In this study we assessed the relationship between HS-CRP and uric acid with LVEF and Killip Class in patients with acute myocardial infarction [AMI]. In a cross sectional study, 188 patients [63 females and 125 males] with AMI [STEMI] who were admitted in CCU ward in Emam Khomeini Hospital, Tehran/Iran, were entered. Uric acid and HS-CRP were measured within first day of admission. We measured ejection fraction [LVEF] and used Killip classification system. The mean age of patients was 60.4 +/- 9.2 years. The mean of uric acid was 5.9 +/- 1.6, 6.6 +/- 2.1, 7.1 +/- 2.1 and 9.4 +/- 1.3 in patients with Killip Class I, II, III and IV, respectively [P=0.005]. The mean of HS-CRP was 1.9 +/- 1.4, 14.2 +/- 10.9, 12.2 +/- 10.9 and 15.7 +/- 6.7 in patients with Killip Class I, II, III and IV, respectively [P=0.005]. There was a relationship between HS-CRP and LVEF [Correlation coefficient=-0.788, P<0.001], but there was not between uric acid and LVEF [Correlation coefficient=-0.111, P=0.129], The plasma concentration of C-reactive protein correlated with LVEF and Killip Class in patients with AMI but serum uric acid was just correlated with Killip Class IV. It seems that plasma concentrations of HS-CRP and uric acid are useful for prediction of development of heart failure in AMI patients. More future studies are necessary for final judgment