RESUMO
The aim of this study was determining the relationship between personality traits and happiness in patients with major thalassemia. The design of this study was descriptive [correlational study]. The target population of this study was all under-treated patients with major thalassemia in Amirkola thalassemia center in 2011. Among these patients, 150 patients were sampled using simple random sampling method and Morgan's table. The data were analyzed by means of calculating Pearson correlation coefficients and multiple linear regression analysis. The patients were asked to complete NEO-five factor Inventory [short form] and Oxford happiness inventory. Based on the results, the coefficient of regression analysis of NEO personality factors [big five] and happiness was 0.45, which shows a linear relationship between personality factors of NEO and happiness in patients with thalassemia. Thus, there is a statistically significant relationship among personality traits [neuroticism, extroversion, openness, agreeableness, conscientiousness] and happiness. Among personality traits, extroversion, flexibility, agreeableness and conscientiousness had positive statistically meaningful relationship with happiness i.e. patients with lower scores in neuroticism, were happier