RESUMO
La preeclampsia se constituye como una de las complicaciones más serias del embarazo y una causa importante de mortalidad materna y perinatal. Pese a ser una de las patologías del embarazo más estudiadas, muchas dudas e incertidumbre rondan aún acerca de su mecanismo fisiopatológico. En esta revisión se intenta hacer un análisis sobre las nuevas teorías acerca de la fisiopatología de la preeclampsia, dando énfasis en las distintas moléculas que transfieren el daño placentario hacia el territorio sistémico.
Preeclampsia is one of the most serious gestational disease which causes maternal and perinatal mortality. In spite of being one of the most studied pathologies of the pregnancy there are many concerns around its physiopathology. In this review we attempt to analyze the new preeclampsia physiopathology theories, giving emphasis in the different molecules that transfer the placental damage towards the systemic territory.
Assuntos
Humanos , Feminino , Gravidez , Pré-Eclâmpsia/fisiopatologia , Placenta/fisiopatologia , Apoptose , Estresse OxidativoRESUMO
The environmental lead in the linotype room was 25 percent over the accepted values. Twelve of the 20 workers were poisoned and 3 were highly exposed. Poisoned workers were working in areas with high environmental lead concentrations, were in direct contact with the metal, had plasma lead concentrations over 70 ug/dl and an average exposure time over 17 years. Their clinical picture was not specific and related to plasma and environmental lead concentrations, length of exposure and type of contact. Lead poisoning must be suspected among workers exposed to high environmental concentrations and its treatment consists in withdrawing poisoned subjects from polluted areas.