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@#Objective To observe the effect of Baduanjin on mild cognitive impairment (MCI). Methods From January to June, 2016, 60 patients with MCI in community were randomly divided into control group (n=30) and training group (n=30). The training group accepted training of Baduanjin for six months, and the control group accepted no intervention. They were assessed with Montreal Cognitive Assessment (MoCA) before and after intervention; while the blood lipid, and serum interleukin-6 (IL-6), acetylcholine (Ach), superoxide dismutase (SOD) and malondialdehyde (MDA) were detected. Results The total score, and scores of visual space and executive function, abstract and delayed memory of MoCA were more in the training group than in the control group after intervention (t>3.576, P<0.01), while the level of total cholesterol, IL-6 and MDA decreased (t>2.744, P<0.05), and the level of high density lipoprotein cholesterol, Ach and SOD increased (t>2.922, P<0.01). Conclusion Baduanjin can improve the cognitive function in MCI patients, as well as reducing blood fat, oxidation and inflammation. There may be some relationship between them.
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<p><b>OBJECTIVE</b>To study the antitumor effect of peri-tumor implantation of delayed-release 5-fluorouracil implants on xenograft colorectal tumor in mice.</p><p><b>METHODS</b>Fifty tumor-bearing nude mice were randomly divided into 5 groups. Group A and B were treated with peri-tumor implantation of 5-fluorouracil implants and the dose of 5-fluorouracil was 200 and 100 mg/kg, respectively. Group C and D were treated with peri-tumor injection of 5-fluorouracil solution and the dose of 5-fluorouracil was 200 and 100 mg/kg, respectively. Group E did not receive any treatment. A growth curve was plotted for changes in tumor volume, the weight of the tumor was measured and tumor inhibition rate was calculated.</p><p><b>RESULTS</b>The growth curve was mild in group A and B and steep in group C, D and E. There were statistical differences in tumor volume between groups A and B and other groups and there were no statistical differences in tumor volume among group C, D and E. After 12 days, tumor inhibition rate was 72% in group A, 51% in group B, 8% in group C, and 5% in group C. There were statistical differences in inhibition rate between group A, B and C, D (P<0.05). The weight changes before and after the treatment among the 5 groups were not statistically different. During the study, 1 mouse in group A died, 4 in group C and 1 in group D.</p><p><b>CONCLUSION</b>Delayed-release 5-fluorouracil implants can effectively inhibit tumor growth.</p>