Validation of the Beck Depression Inventory II in HIV-positive patients / Validación del Inventario de Depresión de Beck II en los pacientes VIH-positivos

OBJECTIVE: Research on depression among HIV-positive patients has been limited by the lack of a valid and reliable measure of depression. This project addresses this problem by exploring the internal consistency reliability and the concurrent and discriminant validity of the Beck Depression Inventory- II (BDI-II) using HIV-positive patients in Jamaica. METHOD: Patients from three HIV clinics in Jamaica (n = 191 patients; 61% female, 39% male, mean age 40.5 ± 10 years) were administered the BDI-II along with the Centre for Epidemiological Studies - Depression Scale (CES-D) and the Social Provisions Scale. RESULTS: Overall, the BDI-II was found to have a high degree of reliability (a = 0.89). The scale also had good concurrent validity as evidenced by a high correlation with scores on the CES-D (r = 0.74) and acceptable discriminant validity as demonstrated through a moderate correlation with the Social Provisions Scale (r = -0.42). This pattern of scores suggests that the majority of the variance underlying the BDI-II assesses depression (55%) while a smaller degree of the variability (18%) measures a conceptually similar but distinct concept. CONCLUSION: The BDI-II is a sufficiently reliable and valid measure for assessing depression in HIV-positive patients.

OBJETIVO: La investigación sobre la depresión entre los pacientes VIH-positivos ha estado limitada por la falta de una medida válida y confiable de la depresión. Este proyecto aborda este problema explorando la confiabilidad de la consistencia interna, así como la validez discriminate y concurrente del Inventario de la Depresión de Beck II (BDI-II) usando pacientes VIH-positivos en Jamaica. MÉTODO: A los pacientes de tres clínicas de VIH en Jamaica (n = 191 pacientes; 61% hembras, 39% varones, edadpromedio 40.5 ± 10 anos) se les aplicó el BDI-IIjunto con la Escala de Depresión (CES D) y la Escala de Provisiones Sociales - Centro de Estudios Epidemiológicos. RESULTADOS: En general, se halló que el BDI-II posee un alto grado de confiabilidad (a = 0.89). La escala poseía también una buena validez concurrente, como quedó evidenciado por la elevada correlación con las puntuaciones del CES-D (r = 0.74), Igualmente, se constató que posee una validez discriminante aceptable como lo demuestran las correlaciones moderadas con la Escala de Provisiones Sociales (r = -0.42). Este patrón de puntuaciones sugiere que la mayor parte de la varianza que subyace en el BDI-II da la medida de la depresión (55%), en tanto que un grado menor de la variabilidad (18%) mide un concepto de naturaleza similar pero claramente definido. CONCLUSIÓN: El BDI-II constituye una medida suficientemente confiable y válida para evaluar la depresión en pacientes VIH positivos.

Patterns of depressive symptoms among patients with HIV infection / Patrones de síntomas depresivos entre pacientes con infección por VIH

OBJECTIVE: To identify the level of depressive symptoms among patients with HIV infection and to examine the reported patterns of depressive symptoms not confounded by the physical manifestations of HIV-infection. METHOD: A total of 191 patients with HIV infection (75 males (39%) and 116 females (61%), mean age 40.48 ± 10 years), from three HIV clinics were administered the Beck Depression Inventory - II as well as a demographic questionnaire as part of a larger study. RESULTS: Moderate to severe depressive symptoms were reported by 17.3% of the HIV-infected patients with females reporting significantly higher levels of depressive symptoms than males. A principal components analysis identified three clusters of depressive symptoms: cognitive-affective, negative cognitions and somatic symptoms. The HIV-infected patients were found to display mainly cognitive-affective symptoms of depression. CONCLUSION: HIV-infected patients, especially female patients, may be at an increased risk of experiencing high levels of depressive symptoms. It is recommended that HIV-infected patients be routinely screened for depression, particularly cognitive-affective symptoms of depression.

OBJETIVO: Identificar el nivel de sintomas depresivos entre pacientes con infección por VIHy examinar los patrones reportados sobre los sintomas de depresión, no confundidos por las manifestaciones físicas de la infección por VIH. MÉTODO: A un total de 191 pacientes con infección por VIH (75 varones (39%) y 116 hembras (61%), con edadpromedio 40.45 ± 10 anos), de tres clinicas de VIH, se les aplicó el Inventario de Depresión de Beck II, asi como una encuesta demográfica como parte de un estudio más grande. RESULTADOS: Un 17.3% de los pacientes infectados por VIH, informaron sintomas depresivos de moderados a severos, reportando las hembras niveles de sintomas de depresión significativamente más altos que los varones. Un análisis de los componentes principales identificó tres grupos de sintomas depresivos: cognitivos afectivos, cogniciones negativas y sintomas somáticos. Se halló que los pacientes infectados por VIHpresentaban principalmente sintomas afectivos cognitivos de depresión. CONCLUSIÓN: Los pacientes infectados con VIH, especialmente las hembras, pueden hallarse en un mayor riesgo de experimentar niveles altos de sintomas depresivos. Se recomienda que los pacientes infectados con VIHsean sometidos deforma rutinaria a tamizajes de depresión, particularmente de los sintomas de depresión cognitivos afectivos.

High genetic diversity in human immunodeficiency virus: type 1 in Jamaica / Elevada diversidad genética del virus de la inmunodeficiencia humana: tipo 1 en Jamaica

The subtypes of the human immunodeficiency virus - type 1 (HIV-1) strains from 54 HIV-1 - infected persons including 44 strains which were typed previously by heteroduplex mobility assay (HMA) were determined by DNA sequencing and phylogenetic analysis. Of 54 HIV- infected persons, 92.5% were infected with HIV-1 subtype B and 7.5% with other HIV-1 subtypes including subtypes D (3.7%), A (1.9%) and J (1.9%). In the phylogenetic analysis, the subtype A virus found in the sample clustered with subtype A reference strains and a circulating recombinant form (CRF) reference strain which originates in Central Africa and is circulating in Cuba indicating a close relationship between these viruses. There was 86% concordance between HMA and DNA sequencing in assigning subtype B viruses. For the non-B subtype viruses, there was less concordance between the two methods (67%). The results confirm the predominance of HIV-1 subtype B strains and the high genetic diversity of HIV-1 strains in circulation in Jamaica. The efficacies and some limitations of the HMA as a method of HIV-1 subtyping also were noted. It is important that the HIV/AIDS epidemic in Jamaica be monitored meticulously for possible expansions in non-B subtypes and the emergence of inter-subtype recombinant forms. We recommend that the more expensive DNA sequencing and phylogenetic analysis, including HIV-1 genotyping for antiretroviral drug resistance testing, be used as an adjunct to the more cost-effective HMA to track the HIV/AIDS epidemic in Jamaica.

Los subtipos de cepas de virus de la inmunodeficiencia humana-tipo-1 de 54 personas infectadas con el VIH-1, que incluyeron 44 cepas previamente clasificadas según su tipo mediante ensayo de movilidad de heterodúplex (HMA), fueron determinados mediante secuenciación de ADN y análisis filogenético. De 54 personas infectados con VIH, 92.5% estaban infectadas con VIH-1 subtipo B y 7.5% con otros subtipos de VIH-1 incluidos los subtipos D (3.7%), A (1.9%), J (1.9%). En el análisis filogenético, el virus de subtipo A hallado en la muestra, se agrupa con las cepas de referencias del subtipo A y una cepa de referencia de forma recombinante circulante (CRF), que tienesu origen en África Central y está circulando en Cuba, lo que indica una estrecha relación entre estos virus. Hubo un 86% de concordancia entre el HMA y la secuenciación del DNA en la asignación de virus de subtipo B. Para los virus de subtipo no B, hubo menos concordancia entre los dos métodos (67%). Los resultados confirman el predominio de las cepas del subtipo B del VIH-1, y la alta diversidad genética de las cepas del VIH-1 en circulación en Jamaica. También se señalaron las eficacias y algunas limitaciones del HMA como método de clasificación del VIH-1 en subtipos. Es importante monitorear meticulosamente la epidemia de VIH/SIDA en Jamaica, a fin de detectar posibles expansiones de subtipos no B y la aparición de formas recombinantes inter-subtipos. Recomendamos que por ser ambos métodos más costosos, tanto la secuenciación de ADN como el análisis filogenético - incluyendo el genotipado del VIH-1 para probar la resistencia antiretroviral del medicamento - sean usados como complementos del HMA, el cual es más costo-efectivo, para seguir de cerca el rastro de la epidemia VIH/SIDA en Jamaica.

Voices of the women: feedback from women of child-bearing age who are living with HIV can help improve efficacy of psychosocial interventions / Voces de mujeres: la retroalimentación de mujeres en edad de parir viviendo con VIH puede aayudar a mejorar la eficacia de las intervenciones psicosociales

BACKGROUND: We hypothesized that voluntary counselling and testing during pregnancy are necessary but not sufficient to provide the holistic psychosocial support needed by Jamaican women living with HIV and/or AIDS. Based on this hypothesis, we investigated a range of coping methods and support systems used by HIV-infected women and a group of their HIV-negative counterparts before, during and immediately after their pregnancies. METHODS: Women attending obstetric clinics in urban Jamaica completed a quantitative survey aimed at discovering coping behaviours, social and spiritual support systems. Presurvey focus group studies and key informant interviews contributed to the design of the questionnaire while post-survey focus groups were used to probe the validity of the data gleaned from the questionnaire survey. Survey data were analyzed using non-parametric tests for trend with independent univariate tests. RESULTS: Fifty-five HIV-infected women and 51 HIV-negative women completed the survey. Compared with HIV-negative women, more HIV-infected women reported both feeling depressed (p = 0.07) and having difficulty concentrating (p = 0.05) during the month immediately prior to the study. Other statistically significant differences included: HIV-infected women were more likely to pray, to sleep and to change eating habits in response to worry and stress (p = 0.001 in each instance). Although several women declared religious faith, significantly fewer HIV-infected women were willing to talk to a religious leader about their problems compared to their HIV-negative counterparts (p < 0.001). CONCLUSIONS: Participation of HIV-infected women in post-survey focus groups augmented the survey findings. Many of the women reported negative emotions and some indicated serious challenges in accessing social support. The results point to the need for systematic documentation of psychosocial profiles as part of the approach to caring for these women. In addition, in the Jamaican sociocultural context, we recommend improved training of religious leaders and healthcare providers in psychosocial issues.

ANTECEDENTES: Planteamos la hipótesis de que someterse al asesoramiento y prueba voluntarios durante el embarazo es necesario, pero no suficiente para el apoyo psicosocial holístico que necesitan las mujeres jamaicanas que viven con VIH y/o SIDA. Sobre la base de esta hipótesis, investigamos una serie de métodos de afrontamiento y sistemas de apoyo usados por las mujeres infectadas por el VIH y un grupo de sus contrapartes VIH negativas antes, durante e inmediatamente después de sus embarazos. MÉTODOS: Mujeres que asistían a clínicas obstétricas en áreas urbanas de Jamaica, completaron una encuesta cuantitativa, encaminada a descubrir conductas de afrontamiento, y sistemas de apoyo social y espiritual. Estudios de grupos focales mediante encuestas y entrevistas a informantes claves, contribuyeron al diseño del cuestionario, mientras que grupos focales de post-encuesta fueron usados para investigar la validez de los datos recogidos de la encuesta-cuestionario. Los datos de la encuesta fueron analizados usando tests no paramétricos para tendencia con tests univariados independientes. RESULTADOS: Cincuenta y cinco de las mujeres infectadas con VIH y 51 de las mujeres VIH negativas, completaron la encuesta. En comparación con las mujeres VIH negativas, más mujeres infectadas con VIH reportaron sentirse deprimidas (p = 0.07) y tener dificultades con la concentración (p = 0.05) durante el mes inmediatamente anterior al estudio. Otras diferencias estadísticamente significativas fueron las siguientes: las mujeres infectadas con el VIH mostraron una mayor tendencia a orar, dormir y cambiar sus hábitos alimentarios en respuesta a la preocupación y el estrés (p = 0.001 en cada caso). Aunque varias mujeres declararon tener fe religiosa, significativamente pocas mujeres infectadas con VIH estuvieron dispuestas a hablar a un líder religioso acerca de sus problemas, en comparación con sus contrapartes VIH negativas (p < 0.001). CONCLUSIONES: La participación de mujeres infectadas con VIH en grupos focales de post-encuesta aumento marcadamente los hallazgos de la encuesta. Muchas de las mujeres reportaron emociones negativas y algunas indicaron serios desafíos en cuanto a tener acceso a algún apoyo social. Los resultados apuntan a la necesidad de poseer una documentación sistemática de los perfiles psicosociales como parte del abordaje del cuidado a estas mujeres. Además, en el contexto sociocultural de jamaica, recomendamos mejorar el entrenamiento de los líderes religiosos y los proveedores de salud en cuanto a las problemáticas psicosociales.

The prevalence of mucocutaneous disorders among HIV-positive patients attending an out-patient clinic in Kingston, Jamaica / Prevalencia de trastornos mucocutáneos entre los pacientes VIH positivos que asisten a la consulta externa en Kingston, Jamaica

OBJECTIVES: Skin disorders are thought to occur frequently in persons with HIV/AIDS. To our knowledge, there are no studies in the literature reporting on the spectrum and prevalence of skin disorders in HIV-positive patients in the Caribbean. This study focused on the prevalence and spectrum of skin disorders seen in a population of HIV-positive patients in Jamaica. METHODS: A 5-year retrospective study was conducted by reviewing the records of patients attending a HIV out-patient clinic at the University Hospital of the West Indies in Kingston, Jamaica. RESULTS: Two hundred and eighty-six (286) patients were included in the study. Skin and mucous membrane disorders were documented in 74% of the patients in this series. Inflammatory disorders comprised the largest category of skin disorders followed by fungal infections. The most frequently diagnosed dermatological disorders were papular prurigo, oral candidiasis, dermatophyte infections, herpes simplex infections and seborrhoeic dermatitis. Kaposi's sarcoma was rare. This pattern is similar to those reported from the African continent and other tropical countries. CONCLUSIONS: Dermatological disorders contribute significantly to the morbidity of HIV-positive patients and patterns of skin disorders are similar to those seen in other tropical settings.

OBJETIVOS: Se piensa que trastornos cutáneos ocurren con frecuencia en personas con VIH/SIDA. Hasta donde sabemos, no hay en la literatura estudios que reporten sobre el espectro y prevalencia de los trastornos cutáneos en enfermos VIH positivos en el Caribe. Este estudio centra su atención en la prevalencia y espectro de trastornos de la piel observados en una población de pacientes VIH positivos en Jamaica. MÉTODOS: Se llevó a cabo un estudio retrospectivo a fin de revisar las historias clínicas de pacientes que asisten a una consulta externa para enfermos de VIH en el Hospital Universitario de West Indies en Kingston, Jamaica. RESULTADOS: Doscientos ochenta y seis (286) pacientes fueron incluidos en el estudio. En el 74% de los pacientes en esta serie, se documentaron trastornos de la membrana mucosa y la piel. Los trastornos inflamatorios abarcaron la categoría mayor de los desórdenes de la piel, seguidos de las infecciones fúngicas. Los trastornos dermatológicos diagnosticados con mayor frecuencia fueron el prurigo papular, la candidiásis oral, las infecciones por dermatofitos, infecciones por herpes simplex y la dermatitis seborreica. El sarcoma de Kaposi rara vez se presentó. Este patrón es similar a los reportados desde el Continente Africano y otros países tropicales. CONCLUSIONES: Los desórdenes dermatológicos contribuyen significativamente a la morbilidad de los pacientes VIH positivos, y los patrones de los trastornos de la piel son similares a los observados en otros escenarios tropicales.

Human immunodeficiency virus type-1 (HIV-1) subtypes in Jamaica / Subtipos del virus tipo-1 de la inmunodeficiencia humano (VIH-1) en Jamaica

The subtypes of 141 isolates of human immunodeficiency virus type-1 (HIV-1) from Jamaica were determined by a combination of env and gag heteroduplex mobility analysis (HMA) genotyping. The majority of HIV-1 isolates were subtype B (131/141, 93.0); one (0.8) isolate each of subtypes C, D and E was found and 7 (4.9) were indeterminate. These results and the failure of the sets of primers used to amplify some of the HIV-1 isolates provide strong evidence of genetic diversity of the HIV/AIDS epidemic in Jamaica. Surveillance of the circulating HIV-1 genetic subtypes is a pre-requisite for developing regional vaccine strategies and understanding the transmission patterns of the virus. This is the first study of its kind in Jamaica and the findings complement data from other Caribbean countries. This work supports the view of colleagues from the French and Spanish-speaking Caribbean that an epidemiological network supported by regional laboratories will help track this epidemic accurately with positive outcomes for the public.

Los subtipos de 141 aislados del virus tipo 1 de la inmunodeficiencia humno (VIH-1) en Jamaica, fueron determinados combinando la genotipificación por análisis de heterodúplex (HMA) en los genes env y gag. La mayor parte de los aislados HIV-1 fueron del subtipo B (131/141, 93.0%), se halló uno (0.8%) aislado para cada uno de los subtipos C, D y E, en tanto que 7 (4.9%) fueron indeterminados. Estos resultados y el fallo de los conjuntos de primers usados para amplificar algunos de los aislados de VIH-1, ofrecen fuerte evidencia de la diversidad epidémica del VIH/SIDA en Jamaica. La vigilancia de los subtipos genéticos de VIH-1 en circulación, constituye un pre-requisito, tanto para desarrollar estrategias de vacunas a nivel regional, como para entender los patrones de transmisión del virus. Este es el primer estudio de este tipo en Jamaica, y nuestros hallazgos complementan los datos obtenidos en otros países del Caribe. Coincidimos con nuestros colegas del Caribe francófono e hispano-parlante en cuanto a que una red epidemiológica apoyada por los laboratorios regionales, nos ayudaría a continuar rastreando esta epidemia con exactitud, y con resultados positivos para el público.

Socio-demographic and clinical characteristics of Jamaican adolescents with HIV/AIDS

BACKGROUND: Clinical symptomatology and socio-demographic factors have not been characterized in Jamaican adolescents with HIV/AIDS. METHODS: We studied these factors in 25 HIV-positive Jamaican adolescents, 10-19 years of age, who were seen at the Centre for HIV/AIDS Research, Education, and Services (CHARES) between the years 1996 and 2002. Data were collected between June 2003 and August 2003 from CHARES social work files and The University Hospital of the West Indies (UHWI) medical records. Microsoft Excel was used to compile descriptive statistics for the data. RESULTS: The mean age of HIV diagnosis was 15.6 (+/-3.09) years, and the mean age of enrollment at CHARES was 16.3 (+/- 2.9) years. Consensual sexual intercourse was the most prominent mode of transmission (56), followed by vertical transmission (16), unknown (16), forced sexual intercourse (8), and blood transfusion (4). The predominant clinical presentations among these adolescent patients were generalized dermatitis (77.2) and lymphadenopathy (50). Of the patients for whom clinical status could be determined, 70 were [quot ]Severely Symptomatic [quot]. Of these patients only 14 were recommended for antiretroviral treatment. CONCLUSIONS: These findings reinforce the need to globally incorporate the goal of the 2002 Joint United Nations Programme on HIV/AIDS (UNAIDS) [quot]to provide reproductive health services, including low-cost or free condoms, voluntary counselling and testing, diagnosis and treatment of sexually transmitted diseases and infections for adolescents in order to effectively prevent HIV infection [quot] (1)

A serosurvey of hepatitis B virus, hepatitis C virus, human T lymphotropic virus type-1 and syphilis in HIV-1-infected patients in Jamaica

The seroprevalences of hepatitis B virus (HBV), hepatitis C virus (HCV), human T lymphotropic virus type-1 (HTLV-1) and syphyilis were determined in 129 HIV-1-infected patients using commercially prepared reagents. The seroprevalences were HCV, 0 (0/129); HBV, 37 (48/129); HTLV-1, 5 (6/129) and syphilis, 20 (26/129). Fifteen per cent (19/129) of the patients had active/chronic HBV infection. The seroprevalence of HBV was statistically significantly higher in HIV-1 infected men (24/49, 50 versus 17/80, 21; p = 0.005), while the seroprevalence of syphilis was statistically significantly increased in HIV-1 infected patients in the over-40 age group (10/31, 32 versus 6/53, 11; p = 0.05). These findings throw the spotlight on HBV infection and syphilis and suggest that these two sexually transmitted infections should be carefully surveyed in patients with HIV/AIDS in Jamaica. It is essential for management protocols in Jamaica to include screening for evidence of these co-infections

Improving community care for persons with the acquired immunodeficiency syndrome in Jamaica

A brief review of the HIV/AIDS epidemic in Jamaica is presented along with the details of a pilot programme aimed at training lay persons and practical nurses to assist with home care of persons with AIDS. Current (1997) estimates are that 2 to 4/1,000 Jamaican adults are HIV positive. 2,301 AIDS cases have been reported to the Epidemiology Unit of the Ministry of Health, 55of whom have died. Males represent 62of reported cases (1421) and children < or = 9 years old, 7(170 cases). In 1981 a Family Centre was started at the University Hospital of the West Indies to provide support to persons with AIDS and their families. This initiative identified the need to provide special training to persons who would be responsible for caring the AIDS patient at home, where most patients preferred to be managed. All but three of the 41 persons trained in the pilot programme achieved the required standards of attendance and proficiency. Certificates valid for two years were issued and refresher courses will follow.

Disseminated infection caused by penicillin-resistant gonococci in two jamaicans

Disseminated gonococcal infection due to penicillin-resistant organisms is very unusual. Two such cases occuring at the University Hospital of the West Indies are described. Implications for therapy are discussed

Significance of the tuberculin skin test in pulmonary tuberculosis in Jamaica: comparisons of culture-positive, culture negative and non-tuberculous patients

The results of tuberculin skin tests with PPDS-S done on patients with pulmonary tuberculosis seen over a three-year period (1979-1981) were compared with the results of similar tests done during the same period in a group of persons without tuberculosis. Ninety per cent of patients with culture-positive tuberculosis had positive tuberculin skin tests, compared to 83% of positive tests in the non-tuberculous group. The presence of such a large proportion of positive tuberculin reactions in persons without active disease indicates that the skin test reaction cannot be used on its own to establish the diagnosis of had negative sputum smears and cultures for acid-fast bacilli. Eighty-two per cent of these patients had positive tuberculin skin tests. Invasive diagnostic tests and newer serological diagnostic methods are likely to increase the yield of confirmed positive cases of tuberculosis in the future