RESUMO
Breast cancer is the most frequent cancer among women and also the leading cause of cancer related deaths in women. The patterns of failures in carcinoma breast seem to differ by cell type, pathological stage and by the treatment modality instituted. Breast cancers can recur locally, regionally and distantly. Survival rates decrease progressively as the stage of the disease increases. Aims & Objectives: To evaluate the patterns of failure in patients with Breast Carcinoma after definitive treatment modalities. Methods: We conducted an analytical, nonrandomized, cross-sectional study on the Patterns of Failure in 1238 patients with primary breast cancer who reported to our Regional Cancer Centre from 2002 to 2010. Results: A total of 1238 patients with 1189 females and 49 males were evaluated. Most of the patients were above fifty years of age with breast lump being the most common presentation. Infiltrating ductal carcinoma was the most common histology and stage II being the commonest stage of presentation. Most of the patients were hormone receptor positive and Her 2 neu receptor negative. Overall local failure was 3.9%, regional failure 2.7% and distant failure 22.5%. Overall 5 year disease free survival was 78.4%. Conclusion: The most common form of local failure is chest wall recurrence, regional failure is supraclavicular lymphadenopathy and distant failure is bone metastasis. The 5 year disease free survival is lower for all the stages when compared to world scenario. This may be attributed to more aggressive disease behaviour in our patients.
RESUMO
Introduction: Ovarian cancer is the fourth most common cause of cancer deaths world wide and also the commonest causeof death among all gynecological cancers.Aims and Objectives: To study the clinico demographic profile and treatment patterns of Ovarian Ca in our population.Material and Methods: We conducted an analytical, non-randomized, cross-sectional study on the Clinico-Demographic profileof 731` patients with Ovarian Carcinoma who reported to our OPD between 2008 to 2015.Results: The mean age of patients was 45±1. 49 years. Most common age group of our patients at presentation was 46-60 years.Majority of patients 70% in our study were from rural area. The major clinical presentation of ovarian in our study was pelvic pain(36%) followed by abdominal distention (34%) and ascites (22%). Most common type of ovarian cancer was of surface epithelialtype (94%) followed by sex cord stromal tumor (3%) and germ cell tumour (1. 6%). Most of the cases 61% in the present studyhad presentation at advanced stages (stage III & IV) while as only 39% cases had presented at early stages (stage I & II).Majority of the patients having ovarian tumors underwent surgical staging with surgery in 88% cases. Chemotherapy was themost common adjuvant therapy in 38% patients who had malignant ovarian pathology and had advanced stage of diseases.while as 7 patients (1%) received radiotherapy for brain and bone mets.Conclusion: Majority of patients were from rural background with pelvic pain as most common presenting symptom Most ofour cases presented in late stages of disease. Greater awareness among our community is needed to reduce the morbidityand mortality associated with Ovarian Ca