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Indian J Ophthalmol ; 2001 Sep; 49(3): 173-6
Artigo em Inglês | IMSEAR | ID: sea-70989

RESUMO

PURPOSE: To evaluate the efficacy of topical (1%) and systemic itraconazole against common fungi such as Aspergillus and other filamentous fungi that cause mycotic corneal ulcer. METHODS: A prospective randomised, controlled study was done in 54 clinically suspected cases of fungal keratitis of which 44 were culture proven. Half the cases (n=27) with superficial involvement were treated with only topical itraconazole (1%) and the other half were treated with both topical and systemic itraconazole. RESULTS: Aspergillus, Penicillium and Fusarium were the most common fungi isolated. The ulcer resolved in 42 eyes (77%) and 12 eyes (23%) did not respond well to treatment. Four of 12 non-responding eyes were caused by Fusarium species. CONCLUSION: Itraconazole, given either topically or systemically, is effective in treating mycotic corneal ulcers.


Assuntos
Administração Oral , Administração Tópica , Adulto , Antifúngicos/administração & dosagem , Aspergillus/isolamento & purificação , Úlcera da Córnea/tratamento farmacológico , Estudos Cross-Over , Infecções Oculares Fúngicas/tratamento farmacológico , Feminino , Fusarium/isolamento & purificação , Humanos , Itraconazol/administração & dosagem , Masculino , Pessoa de Meia-Idade , Micoses/tratamento farmacológico , Penicillium/isolamento & purificação , Estudos Prospectivos , Resultado do Tratamento
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