Two new germacrane-type sesquiterpenoids from resin of Commiphora mukul / 中草药

Objective: To investigate the chemical constituents from the resin of Commiphora mukul. Methods: Silica gel and Sephadex LH-20 column chromatographies were used for the purification, and spectroscopic techniques were adopted for the structure elucidation. Results: Two germacrane-type sesquiterpenoids have been isolated from the resin of C. mukul, which were identified to be 1α, 8α, 12α-trihydroxy-2β-methoxy-8, 12-epoxygermacra-7(11), 9-dien-6-one (1) and 1α, 8β, 12α-trihydroxy-2β-methoxy-8, 12- epoxygermacra-7(11), 9-dien-6-one (2). Conclusion: These two sesquiterpenoids are new compounds named as mukulsin A (1) and mukulsin B (2), respectively.