Correlation of High Sensitive C-reactive Protein levels with Mean Arterial Pressure and Serum Calcium in Women with Mild and Severe Pre-eclampsia

Aim:To compare the mean results of serum levels of hs-CRP and calcium in mild and severe pre-eclamptic women with healthy pregnant women and to investigate the relationship, if any between levels of serum hs-CRP with mean arterial pressure (MAP) and serum calcium. Material and Methods:A case control study was performed on 50-50 primigravidas with mild and severe PE as cases as per clinical guidelines and 50 healthy pregnant women as controls. They were all age and parity matched primigravidas at the third trimester of pregnancy. Results:By using ANOVA, statistically highly significant mean values of hs-CRP and serum calcium were observed among all groups (healthy pregnant women, mild pre-eclamptic and severe pre-eclamptic women). Significant positive correlation is found between hs-CRP with MAP, while the negative association is detected among hs-CRP and serum calcium.Conclusion:Serum hs-CRP may be feasible to be used as a sensitive biomarker for determining women at risk of PE. There is a significant influence of calcium supplementation during the antenatal period and the occurrence of pregnancy induced hypertension.

Neck Dissection in Verrucous Carcinoma: A Surgical Dilemma.

Oral verrucous carcinoma (OVC) is a distinct low grade variant of squamous cell carcinoma (SCC) of the oral cavity. OVC is a rare tumor representing only 3-4% of all carcinoma. OVC is characterized by a slow growing, painless, broad based verrucous or wart like papillary lesion. Th e lesion lacks ulceration and has a propensity for local invasion rather than metastatic spread. Transformation of VC to anaplastic or poorly diff erentiated SCC is about 30-40%. Surgical excision with adequate margins of resection seems to be the clear preference for treatment. Th e need for neck dissection is an important consideration in planning therapy for OVC. Th e aggressive clinical presentation of the tumor often sways clinical judgment in favor of performing lymph node dissection, especially in the presence of clinical lymphdenopathy. It is reasonable to consider a selective neck dissection such as supra-omohyoid neck dissection in situations where there is uncertainty regarding the pathological diagnosis in the phase of clinically suspicious lymphdenopathy. Here we are presenting a case report of OVC in 65-year-old male patient treated with surgical excision and right side supra-omohyoid neck dissection.

Association of TNF – α and uric acid in women with pre-eclampsia.

Background: TNF – α, a cytokine of a generalized intravascular inflammatory reaction, has been also shown to cause microvascular protein leakage and hypertrygliceridemia which are associated with pre-eclampsia. Increased serum uric acid is also associated with hypertension. Aims & Objective: To study the relationship between Tumour Necrosis Factor – alpha (TNF – α) with uric acid and to access the role of TNF – α as a determinant of Pre-eclampsia in women. Material and Methods: 100 patients with pre-eclampsia were studied out of which 50 were mild and 50 were severe pre-eclamptics. They were compared with 50 healthy subjects. Subjects were of similar gestational age, body mass index (BMI) and parity matched. They were all primigravidas at third trimester of pregnancy. Results: All studied subjects belonged to age group 28-40 years. The difference in mean age of healthy subjects and pre-eclamptics was non-significant (P=0.8). BMI values were ranged from 18-43 kg/m2. No significant difference was observed between healthy pregnant women and pre-eclamptics. Serum TNF – α co-related significantly with Mean Arterial Pressure (MAP) and Uric acid levels. The association of TNF – α with uric acid was considerably significant compared to its association with other variables. The result showed that TNF – α is a strong determinant of pre-eclampsia. Conclusion: A co-relation exists between TNF – α and uric acid. The observed co-relation indicates that monitoring TNF – α and uric acid levels in Pre-eclamptic women might serve to help prevent the development of pre-eclampsia in pregnant women.