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Objective To investigate the short-term efficacy of treating thyroid multiple-nodule by Ultrasound-guided microwave ablation in one-session,and to evaluate its safety and effect.Methods Treatment and follow-up data of 85 patients with benign thyroid nodules underwent tUltrasound-guided microwave ablation in one-session were retrospectively analyzed.Results Symptom scores and cosmetic scores increased with the increasing number of nodules ablated before ablation (P ＜ 0.001),as well as the ablation time (P ＜ 0.001).However,there was no significant difference in the amount of isolation belt and intraoperative pain score between the groups.There were no serious complications such as recurrent laryngeal nerve injury and massive hemorrhage in 85 cases underwent tUltrasound-guided microwave ablation in one-session.Compared with the thyroid function,there was no significant difference on before the ablation and 1,3,6 months after ablation.Postoperative 6 months,the maximum volume of nodule and the total volume of the nodules were reduced 63％ and 69.5％,respectively.After ablation,both the symptom scores and cosmetic scores were improved significantly.On 6 months after ablation,the symptom scores decreased from (4.41 ± 1.75) cm to (1 ± 0.76) cm,and the cosmetic score3 decreased from 2.27 ± 0.81 to 1.25 ± 0.43.Conclusion Ultrasound-guided microwave ablation could treat multiple thyroid nodules effectively and protect the physiological function of thyroid,which was worthy of further promotion in clinical application.
RESUMO
Objective To investigate the correlation between the hemodynamic characteristics of time intensity curve(TIC) by contrast enhanced ultrasound(CEUS) and the expression of antigen Ki-67 of the 4 different clinic stages (T0 andTis,T1 ,T2,T3) in ductal carcinoma in order to predict the grade of the expression of antigen Ki-67 and clinic stages.Methods Masses founded in 80 cases proved by pathological test after resection or needle biopsy were divided into 4 groups base on clinic stages:group 1(T0 andTis) , group 2(T1),group 3(T2),and group 4(T3).Some parameters gained after analyzing TIC of CEUS would be used to make a rank correlation analysis with the expression grade of antigen Ki-67 through immunohistochemical diagnosis.A regression equation would be gained from those parameters which had a correlation with the expression grade of antigen Ki-67 (P < 0.05). Results Most TIC of ductal carcinomas were possessed of the characteristics of fast in and slow-out.Compared to the other three groups,group 4(T3) had significant differences in arrive time,time to peak,arrive intensity,peak intensity and area under curve.Compared to group 1(T0 andTis),group 4(T3) had significant differences in continuous time and rising curve's slope and group 3(T2) has significant differences in arrive intensity and area under curve. Parameters entered the regression equation through mult-variable linear regression analysis were arrive time,continuous time,peak intensity and rising curve's slope.R square was 0.83 1 and adjust R square was 0.822.Through the regression equation verification,5 cases accorded with the clinic stages standard of ductal carcinoma.Conclusions The hemodynamic characteristics of time intensity curve (TIC) by contrast enhanced ultrasound had a good correlation with the expression grade of antigen Ki-67 of the 4 different clinic stages in ductal carcinoma.The regression equation had a good explanatory and degree of fitting,it can be used to predict the expression grade of antigen Ki-67 and indirectly forecasts clinic stages of ductal carcinoma.