Role of drug transporters in rational use of drugs at high altitude area / 中南大学学报(医学版)

Pharmacokinetics plays a key role in rational use of medicines.Many factors can affect the drug's pharmacokinetics.Previous studies mainly focused on the impact of hypoxia on hepatic drug metabolizing enzyme,but uncommon on drug transporters.Actually,drug transporter is a key factor for activation of the drugs transport across the cell membrane into the inside of cells,such as multidrug resistance protein (MDR),breast cancer resistance protein (BCRP),multidrug resistance associated protein (MRP),organic cation transporter (OCT),organic anion-transporting polypeptide (OATP),organic anion transporter (OAT),qligopeptide transporter (PEPT),etc.They are widely present in the small intestine villus epithelial cells,renal tubular epithelial cells,hepatocytes and biliary epithelial cells.They play a very important role in drug absorption,distribution,metabolism and excretion.The changes in drug transporters under hypoxia in intestinal could affect the bioavailability of drugs;the changes in drug transporters in organs could affect drug's distribution,subsequent drug's indications and adverse reactions;the changes in drug transporters in liver and kidney could affect the metabolism and excretion rate of drugs,thereby the drug's residence time and half-life.

Application value of ultrasonic guided percutaneous portal vein punctures on autologous stem cells transplantation for the patients with dccompensated liver cirrhosis / 中华超声影像学杂志

ObjectiveTo explore the viability,security and the curative effect of ultrasonic guided percutaneous portal vein puncture on autologous stem cells transplantation for patients with decompensated liver cirrhosis.MethodsSixty-four patients of decompensated liver cirrhosis with ascites were treated by autologous stem cell transplantation through ultrasonic guided percutaneous portal vein puncture.The clinical symptoms after transplantation,postoperative adverse reaction,the results of liver function tests were observed.Results After stem cells transplantation,patients' liver function got better obviously,laboratory indicators were better,postoperative adverse reaction and complication were less than those of 87patients treated with autologous stem cell transplantation into hepatic artery multilevel branch by pipe(P＜0.05).Conclusions Ultrasound guided percutaneous portal vein puncture on autologous stem cells transplantation is the viability,security,less side effect and effective for treatment patients with decompensated liver cirrhosis.It can be used as the clinical treatment methods for patients with middle-late liver cirrhosis.

Improving patient satisfaction with the doctor-patient information exchange platform / 中华医院管理杂志

The paper described the necessity of the doctor-patient information exchange platform,and defects found in existing platforms. Such a platform is conducive to higher hospital informationization, better patient satisfaction, and better social and economic benefits of the hospital.The hospital may improve its quality of care and patient satisfaction by means of the platform