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Diabetes mellitus (DM) remains a great challenge in treatment due to pathological complexity. It has been proven that phytomedicines and natural medicines have prominent antidiabetic effects. This work aimed to develop selenium-layered nanoparticles (SeNPs) for oral delivery of mulberry leaf and extracts (MPE), a group of phytomedicines with significant hypoglycemic activities, to achieve a synergic antidiabetic effect. MPE-loaded SeNPs (MPE-SeNPs) were prepared through a solvent diffusion/ reduction technique and characterized by particle size, potential, morphology, entrapment efficiency (EE) and drug loading (DL). The resulting MPE-SeNPs were 120 nm around in particle size with EE of 89.38% for rutin and 90.59% for puerarin, two marker components in MPE. MPE-SeNPs exhibited a slow drug release and good physiological stability in the simulated digestive fluid. After oral administration, MPE-SeNPs produced significant hypoglycemic effects both in the normal and diabetic rats. intestinal imaging and cellular examinations demonstrated that MPE-SeNPs were provided with outstanding intestinal permeability and transepithelial transport aptness. It was also revealed that MPE-SeNPs could alleviate the oxidative stress, improve the pancreatic function, and promote the glucose utilization by adipocytes. Our study provides new insight into the use of integrative nanomedicine containing phytomedicines and selenium for DM treatment.
RESUMO
ObjectiveTo explore the clinical value of diltiazem in patients with acute left heart failure caused by hypertension and rapid atrial fibrillation. MethodsNinety-nine hospitalized patients with acute left heart failure caused by hypertension and rapid atrial fibrillation were randomly divided into observation group (61 cases) and control group (38 cases). Conventional therapy was given in the two groups and diltiazem was added in observation group. Blood pressure, heart rate and respiration rate was compared.ResultsAfter treatment for 30 min and 1 h, the levels of SBP and DBP were significantly lower in observation group than those in control group (P ＜ 0.01 ). After treatment for 30 min, the rate of dyspnea disappearing,heart rate decreasing below 100 times/min, rale in lung decreasing or disappearing, quiet and sweat disappearing [44.3％ (27/61) ,42.6％ (26/61) ,44.3％ (27/61),41.0％ (25/61)] were significantly higher than those in control group [18.4％(7/38), 15.8％(6/38), 18.4％(7/38), 15.8％(6/38)] (P ＜ 0.01 ). After treatment for 1 h, the levels of above mentioned index were significantly higher than those in control group (P ＜ 0.01 ). ConclusionDiltiazem has exact effect in the treatment of acute left heart failure caused by hypertension and rapid atrial fibrillation, and is valuable in clinic.