Prognostic value of platelet dynamic changes in patients with extracorporeal membrane oxygenation / 中华急诊医学杂志

Objective:To investigate the predictive value of platelet dynamics on the prognosis of 28-day in patients with extracorporeal membrane oxygenation (ECMO).Methods:From January 2017 to December 2020, 60 patients from the Emergency Medicine Center of the First Affiliated Hospital of Nanjing Medical University received ECMO for life support. The baseline data of the patients were collected, the minimum value of platelets on day 1-7 of the machine was calculated, and the platelet change value and change rate were calculated. The patients were divided into the survival group and death group according to the 28-day survival status after ECMO was installed, and the receiver operating curve (ROC) was drawn based on the platelet change value and change rate to evaluate its predictive value for prognosis.Results:Among patients receiving VV-ECMO, the platelet change value and change rate on day 7 had the best prediction effect on the patient's 28-day outcome ( AUCΔPLT7=0.772, P=0.016; AUCΔPLT7%=0.764, P=0.020), when the platelet change value was 4×10 9/L as the critical value, the sensitivity was 0.857, the specificity was 0.615, and when the platelet change rate was -28.99% as the critical value, the sensitivity was 0.857, the specificity was 0.615, and when the platelet change rate was -28.99%. The sensitivity was 0.643 with a specificity of 0.846. In patients receiving VA-ECMO, the platelet change rate on day 6 predicted the best effect on the patient's 28-day outcome ( AUCΔPLT6%= 0.707, P = 0.045). When the platelet change rate was -26.19% as the critical value, the sensitivity was 0.842 and the specificity was 0.643. Conclusions:Platelet dynamic changes of platelets are correlated with the 28-day prognosis of patients receiving ECMO, and the combination of platelet change value and the critical value of change rate can better predict the poor prognosis of patients in both ECMO modes.

Impact of dispatcher-assisted cardiopulmonary resuscitation on survival after out-of-hospital cardiac arrest: A Meta-analysis / 中华急诊医学杂志

Objective:To evaluate the outcome of the patients receiving dispatcher-assisted cardiopulmonary resuscitation (DA-CPR) delivered by first-responders who witnessed the out-of-hospital cardiac arrest (OHCA) before the Emergency Medical Service (EMS) arrived.Methods:We performed a search of the relevant literature exploring major scientific databases. We assessed the quality of the included cohort study according to the Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. Meta-analysis was performed on three outcome indicators (recovery of spontaneous circulation survival to hospital discharge and survival with favourable neurologic outcome) using the Revman5.3 software.Results:A total of 21 studies with 349 822 patients were selected for the meta-analysis, including 182 125 patients in the DA-CPR group and 167 697 in the CPR-only group. The meta-analysis showed no significant difference between the DA-CPR and CPR-only groups in ROSC [ RR=1.10, 95% confidence interval ( CI): 0.94-1.29, P=0.24], survival to hospital discharge ( RR=1.10, 95% CI: 0.90-1.34, P=0.34) and survival with favourable neurologic outcome ( RR=1.01, 95% CI: 0.79-1.28, P=0.97) of the patients in America, Japan and Korea. However, there was a significant difference between the DA-CPR and the CPR-only groups in ROSC ( RR=2.61, 95% CI:1.53-4.46, P=0.0005), survival to hospital discharge( RR=6.08, 95% CI: 1.84-20.04, P=0.003), and survival with favourable neurologic outcome( RR=9.76, 95% CI: 1.87-51.02, P=0.007) of the patients in China. Conclusions:The overall effect of DA-CPR is significantly different for each country. In detail, DA-CPR offers a survival advantage (Return of spontaneous circulation, survival to hospital discharge and survival with favourable neurologic outcome) over CPR alone in China but no advantage in developed countries.

Clinical pathologic analysis on 3 724 cases of salivary gland tumors / 中华口腔医学杂志

Objective@#To investigate the incidence and proportion of salivary gland tumors in order to provide new thinking for clinical diagnosis and treatment.@*Methods@#Collected 3 724 cases salivary gland tumors diagnosed by Pathology Department of Hospital of Stomatology, Jilin University from January 1961 to December 2016. The pathological diagnosis referred to the fourth edition of head and neck-salivary gland tumor histopathological classification standard of WHO. The database was established with Microsoft Excel and analyzed with SPSS 18.0. Made a retrospective analysis and comparison on the numbers of all cases in terms of types, site, gender and age and estimate the trend with the time interval of 8 years, and then make a judgement of the trend of salivary tumors.@*Results@#The benign tumors were more common than the malignant among all periods, the proportion of all tumors was about 2.92∶1; The top three benign tumors were polymorphous adenoma [73.78% (2 046/2 773)], Warthin tumor [15.80% (438/2 773)] and base cell adenoma [8.37% (232/2 773)]. Polymorphous adenoma took up 54.94% (2 046/3 724) of all tumors. The top three malignant tumors were mucous epidermoid carcinoma [31.44% (299/951)], adenoid cystic carcinoma [26.92% (256/951)] and adenocarcinoma [11.88% (113/951)]. As for sex, male female ratio was 0.83∶1. As for site, the pathogenic site of tumors was mainly in parotid gland [63.75% (2 374/3 724)], followed by palatal gland [16.50% (615/3 724)], then submandibular gland [12.67% (472/3 724)]; As for age, the common age was between 51 and 60 years old [23.74% (884/3 724)], followed by 41 to 50 years old [21.56%(803/3 724)].@*Conclusions@#The incidence of benign and malignant salivary gland tumor increased in the 56 years. Females showed a higher incidence. The majority tumors occurred in parotid gland. The most common salivary gland tumor was pleomorphic adenoma and the most common malignant tumor was mucous epidermoid carcinoma. The most common age was in 51-60 years old period.

A retrospective clinical study of 3 382 cases of malignant oral maxillofacial tumors / 中华口腔医学杂志

To investigate the incidence of malignant tumors in oral and maxillofacial region and the pathological features of various tumors, a total of 3 382 cases of malignant tumors in oral and maxillofacial region admitted to Jilin University from Januarary 2000 to December 2017. The characteristics of age, sex, location and pathological types of all kinds of tumors were analyzed. The median onset age is 57 years old, 51 to 70 years old is a high-risk age group, the ratio of male to female was 1.9∶1. The primary tumor location is tongue, gingiva and floor of mouth. Epithelial, lymphatic hematopoietic system, bone and soft tissue were the three major sources of tumor tissue, and squamous cell carcinoma was the most common pathological type (65.1%), followed by mucoepidermoid carcinoma and adenoid cystic carcinoma. In summary, oral and maxillofacial malignancies have a high incidence in elderly men, and tongue is the most common site of disease. Epithelial-origin and squamous cell carcinomas are the first of their origins and pathological types, respectively.

Influence of α-Si3N4 and SP1SiO2 fusing conditions and filler ratios in properities of dental resin composites / 吉林大学学报(医学版)

Objective: To detect the optimal fusing temperature, the fusing time and the best filler ratio of α-Si3N4 and SP1SiO2, and to clarify their influence in the properities of dental resin composites. Methods: The α-Si3N4 crystalline were mixed with SP1SiO2 particle at the ratio of5:l (Wt%), and then were sintered under 500°C, 650°C, 800°C, 950°C and 1 100°C at a rise rate of 250 · h-1 and maintained for 10 min, 30 min and 3 h, respectively (used as α-Si3N4-SP1SiO2 groups). SP1SiO2 particle, α-Si3N4 crystalline, mixed and non-fused α-Si3N4 and SP1SiO2 (mixed) groups were set up, and two commercially available resin composites were selected and used as control groups. And they were fully mixed with the resin matrix in 60% (Wt%) after the treatment of cyclohexane solution to make the samples. The flexural strength of specimen was tested and the morphology of section under SEM was analyzed. Then α-Si3N4 was mixed with SP1SiO2 in a ratio of 2; 1. It was fused under the optimal fusing conditions. After the treatment of cyclohexane solution, it was mixed and polymerized with the resin matrix in the proportions of 20%, 40%, 60%, 70% and 75% (Wt%), and two kinds of commercially available resin composites were selected and used as control groups. The flexural strength of specimens was tested and the morphology of section under SEM was analyzed. Results: The maximum flexural strength value in α-Si3N1-SP1SiO2 groups was at 800°C and 30 min (P>0. 05); the flexural strength value was significantly higher than those in SP1SiO2 group, α-Si3N1 crystalline group, mixed group and two control groups (P<0. 05), and the morphology of section SEM was consistent with the mechanical properties. The flexural strengths of resin composites were increased gradually with the increasing of filler ratios of α-Si3N4 and SP1SiO2 fusion from 20% to 60% (P<0. 05); the flexural strength values of resin composites with the proportion of 60%-70% were not increased significantly, the flexural strength values of resin composites with the proportion of 70%-75% were decreased, and the flexural strength values of the resin composites with the proportion of 60% and 70% were significantly higher than those of resin composites with the proportions of 20%, 40%, 75% and control groups; the morphology of section under SEM was consistent with the mechanical properties. Conclusion: The optimum fusing condition for α-Si3N4 and SP1SiO2 is 800°C for 30 min, and the best filler ratio of α-Si3N4 and SP1SiO2 is 70%.

Comparison and research on detection rate of lung lesions of 16 slice spiral CT low dose of TLC technique and conventional radiography / 中国医学装备

Objective:To explore and analyze detection rate of lung lesions of 16 slice spiral CT low dose of TLC technique and conventional radiography. Methods: Selected 120 lung disease patients in our hospital , they were randomly divided into 16 layers of low dose spiral CT examination examination group and conventional thin chest lung examination group, each group had 60 patients,compared two groups’ detection rate of contrast. Results:16 thin layer of low-dose spiral CT technology inspection found 8 pulmonary fibrosis patients, including 6 emphysema patients, 5 tuberculosis patients, 2 lung cancer;there were 21(35%.00) lung disease in total.While conventional chest X-ray examination revealed 2 pulmonary fibrosis, 1 man tuberculosis, 2 lung cancer.There were 5(8.33%) lung disease in total. The detection rates of 16 slice spiral CT low dose of TLC examination of lung and conventional radiography examination of lung lesion had differences (x2=12.5696, P<0.05). Conclusion:16 slice spiral CT low dose of TLC inspection has higher detection rate compared with the conventional chest X-ray examination on lung lesions ,it can exam lung disease effectively, its radiation damage on physical examination and medical staff is small, and can be widely applied, it is worth to popularize.

Chemical constituents from Callicarpa nudiflora and their hemostatic activity / 中国中药杂志

<p><b>OBJECTIVE</b>To study the hemostatic effect of chemical constituents from Callicarpa nudiflora.</p><p><b>METHOD</b>The chemical constituents were isolated and purified via silica gel and Sephadex LH-20 column chromatography. Their structures were determined on the basis of spectral analysis. prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and fibrinogen (FIB) of the constituents rabbit blood samples were tested with rabbit blood in vitro.</p><p><b>RESULT</b>Eleven compounds were isolated and identified as two diterpenens: 7alpha-hydroxy sandaracopimaric acid (1), 16, 17-dihydroxy-3-oxophyllocladane (2). Two phenoic glycosides: acteoside (3), samioside(4). Three triterpenes: 2alpha, 3alpha, 24-trihydroxy-ursa-12-en-28-oic acid (5), 2alpha, 3alpha, 19alpha-trihydroxyursa-12-en-28-oic acid-28-0-beta-D-glucopyranosyl ester (6), and 2alpha, 3alpha, 19alpha, 23-tetrahydroxy-ursa-12-en-28-oic acid-28-0-beta-D-glucopyranosyl ester (7). Four flavones: rhamnazin (8), 5-Hydroxy-3, 7, 4'-trimethoxy-flavone (9) , 5-Hydroxy-3, 7, 3', 4'-tetramethoxyflavone (10), and luteoloside (11). All Compounds cannot significantly shorten the PT (P < 0.01), compounds 3, 4, 7, 10 can remarkedly increase APTT (P < 0.01), compound 5 can prolong the T( P < 0.01) obviously, and compound 8 can significantly increase the contents of FIB (P < 0.01).</p><p><b>CONCLUSION</b>Compounds 2, 4 and 10 were isolated from this genus for the first time, and compounds 1, 3, 5, 6, 7 and 9 had been isolated from this plant for the first time. The hemostatic effect of C. nudiflora may be related to the activation of the intrinsic blood coagulation system.</p>

Synthesis and anti-platelet aggregation activities of ferulic acid esters / 中国药科大学学报

Aim: To study the synthesis and anti-platelet aggregation activities of ferulic acidic esters so as to search for novel antithrombus agents. Methods: Based on prodrug strategy and combination principles, monoesters were first synthesized by reaction of ferulic acid with alcohols, and then the monoesters were coupled with aspirin to afford bis-esters. The target compounds were assayed for anti-platelet aggregation activities in vitro. Results: Sixteen target compounds and eight sideproducts including 15 new compounds were synthesized and their struc-tures were determined by IR, MS and ~1H NMR. The results demonstrated that some tested compounds exhibited potential anti-platelet aggregation activities. Conclusion: The bis-esters of ferulic esters coupling with aspirin with 4 to 5 carbons in side chain might be used as lead compounds for further study in searching for novel antithrom-bus agents.

The influence of fusing conditions on the surface structure and morphology of SP1 SiO_2 in dental resin composites / 实用口腔医学杂志

Objective: To evaluate the influence of fusing conditions on the surface structure and morphology of the SP1 SiO2. Methods:The SP1 SiO2 samples were sintered under 500, 650, 800, 950 and 1 100 ℃ at a rate of 250 ℃/h and maintained for 10, 30 min, 3 h respectively. The surface structure was characterized by FT-IR. Results:The characteristic peak of Si-OH bond at 958 cm-1 took off gradually with the rising temperature and prolonged time. Under the conditions of 950 ℃ maintained for 10 min and 30 min, and 650 ℃ maintained for 3 h, it disappeared completely. The particles of the SP1 SiO2 became larger while the size distribution became narrow. Conclusion: Fusing conditions can affect the Si-OH content and the size of the SP1 SiO2, as well as the size of distribution.[

STUDIES ON THE STRATEGY OF MEDICAL SERVICE AND MILITARY MEDICAL EQUIPMENT RESEARCHES / 医疗卫生装备

The present thesis analyzes and discusses the concept of medical service strategy and its relation to medical equipment researches theoretically According to the prediction of future war,the author puts forward the idea and method of present strategy as well as developing strategy for medical equipment researches.And it also showes the critical points of them.