Can Open Fracture Debridement Improve Postoperative Wound Infection?.

Damaged soft tissues provide an ideal environment for bacterial growth and subsequent infections. This study was to evaluate the spectrum of bacterial contamination of predebridment and postdebridment measures in patients with open fractures and to study the best timing suitable for eradication of the micro-organism in a tertiary hospital. These studies was conducted over 112 patients open fracture wound episodes with or without overt signs of infection were included in this study. A patient is considered to have an open fracture wound infection when clinical signs and symptoms of infection were present. Four swabs were taken for each patient, the first was taken as pre debridement swab, the second was post debridement swab, the third swab was after 3 days after debridement and the fourth was 7 days after debridement. Specimens were examined aerobically and anaerobically. Of the 112 wound specimens examined by Gram stain, 66.96% were positive for the presence of bacteria. The Gram-positive and Gram-negative bacteria accounted for 58.66% and 41.33%, respectively. S. aureus (44.2%) was the dominant isolate. The most effective drugs against the tested Gram-positive were amoxicillin/clavulonic acid, erythromycin, vancomycin, cefuroxime and ampicillin. Whereas, the most effective drugs against the tested Gram-negative bacteria were gentamicin, ciprofloxacin, tazocin, imipenem and aztreonam. Postoperative bacterial infection can be decreased if debridement was done at optimum time.

Expression of Eotaxin and RANTES in Nasal Polyps versus Healthy Nasal Mucosa, a Case Control Study.

Aims: To investigate the levels of the chemokines; eotaxin and RANTES in chronic rhinosinusitsis with nasal polyposis in comparison to their levels in control healthy nasal mucosa to evaluate if they might play a role in pathogenesis. Study Design: We performed a prospective case control study. Place of Study and Duration: This study was performed in Otorhinolarngology Department Mansoura University Hospitals, Egypt. Methodology: It included 60 patients suffering from chronic rhinosinsuitis with nasal polyposis, in addition to 20 subjects that were included as control. Nasal tissue samples were collected from all cases and control to estimate the levels of eotaxin and RANTES by ELISA. Results: The estimated levels of eotaxin and RANTES in nasal polyps were higher than their measured levels in healthy nasal mucosa from control group and the results were statistically significant. Conclusion: The measured levels of eotaxin and RANTES suggest that they may have a role in pathogenesis of chronic rhinosinusitis with nasal polyposis and can be considered as a good target for medical therapy until supported by further studies.