Study of coagulation profile and platelet indices in pregnancy induced hypertension with special reference to preeclamptic and eclamptic patients

Background: Hypertensive disorders of pregnancy affect about 10% of all pregnant women around the world. A variety of haematological abnormalities may occur in women with Pregnancy Induced Hypertension (PIH), thrombocytopenia being the most common. There is also a definite exaggeration of the hypercoagulable state during PIH. A strong relationship exists between the two most important causes of maternal mortality and morbidity worldwide: Preeclampsia and Post-partum hemorrhage. The aim of this study was to find out the changes that occur in the coagulation profile and platelet indices in PIH as compared to that in normal pregnancy and if they can be used as a reliable indicator of the onset and severity of Preeclampsia and eclampsia.Methods: This was a hospital based analytical prospective study carried out in R. G. Kar Medical College, between January 2017 to June 2018 on 120 patients with PIH. The study parameters included Platelet count, Platelet Distribution Width (PDW), Mean Platelet Volume (MPV), Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT).Results: The results showed significant decrease in platelet count in preeclampsia and eclampsia patients when compared to normotensive patients. Also, there was significant increase in MPV and PDW in preeclamptic and eclamptic patients. Coagulation profile showed increased PT and APTT both in preeclamptic and eclamptic patients with eclamptic patients having significantly higher APTT than other groups.Conclusions: Thus, authors came to the conclusion that platelet indices and coagulation profile can be used as a reliable early indicator of onset and severity of preeclampsia and eclampsia.

Evaluation of endoscopic biopsy in gastric lesions with a special reference to the significance of mast cell density.

Various studies have shown the role of mast cells in chronic inflammatory states and in tumor growth. The study is designed to have an idea of the relationship of mast cell density (MCD) to gastric ulcer and cancer, to verify whether mast cell accumulation occurred in the two conditions especially in Indian patients and thus postulate that therapeutic strategies against mast cell mediators could be useful in treatment. Also, we want to review literature and attempt to explain our findings. A total of 240 patients, who underwent their first endoscopy and biopsy for a span of 21/2 years were studied retrospectively. Out of these, 210 cases that were either gastric ulcers or cancer were chosen for this MCD study. Biopsies were sectioned and stained routinely. Toluidine blue stain and copper grid was used to calculate MCD. Student's t-Test was used to calculate the statistical significance of MCD. MCD in benign ulcers was much higher than in control subjects. MCD in well-differentiated cancers showed MCD higher than control. Poorly-differentiated adenocarcinoma showed lower MCD than well-differentiated adenocarcinoma. It was concluded that the accumulation of mast cells in gastric ulcers is an inflammatory response. MCD is increased in well-differentiated gastric cancers, which may be a mast cell mediated immune response or mast cells may have a role in tumor angiogenesis and produce factors for tumor progression. Poorly-differentiated adenocarcinoma apparently lacks mast cell mediated anti-tumor response in some unexplained way.

Coexistence of a mature teratoma and mucinous cystadenocarcinoma in the same ovary--a case report.

A case of right sided abdominal lump with pain in a 45 years female was presented. Radiological investigation revealed a multiloculated cystic mass with a few mural nodules arising from right ovary. The tumor was removed by exploratory laparotomy and histopathological examination showed coexistence of dermoid cyst with mucinous cystadenocarcinoma in the same ovary. Left ovary and uterus was healthy and there was no tumor extension or omental deposits. Postoperative period was uneventful.