RESUMO
Objective: To compare the effect of intravitreal triamcinolone [IVT] alone with combined intravitreal triamcinolone [IVT] and intravitreal bevacizumab [IVB] on central macular thickness [CMT] in patients of diabetic macular edema [DME]
Study Design: Randomized control trial
Place and Duration of Study: Armed Forces Institute of Ophthalmology, Jun 2013 to Dec 2013
Material and Methods: Eighty patients were included in the study through non probability consecutive sampling and were randomized to IVT alone or IVT + IVB group using random number table. Pre and post injection [12 weeks] CMT were recorded and intra and inter group comparison was performed
Results: Both groups showed statistically significant reduction in mean CMT at 12 weeks [p<0.05]. In Group A, mean CMT reduction at 12 weeks was 64.33 microns [SD=15.17] while in Group B it was 75.18 [SD=20.82]. On comparison, IVT + IVB group was more effective in reducing CMT with statistically significant difference [p=0.009]
Conclusion: Intravitreal triamcinolone used in combination with IVB is more effective in reducing central macular thickness in diabetic macular edema [DME] than intravitreal triamcinolone alone