Life Without Limbs: Tetra-amelia

Amelia is defined as the complete absence of the skeletal parts of a limb. Tetra- amelia, is the absence of all thefour limbs is a very rare condition with an incidence range of 1.5–4/100,000 births. Many factors causingvarious limb defects are genetic, environmental (teratogens), vascular compromise by amniotic bands andconditions like oligohydraminos and maternal diabetes. Point mutation in the WNT gene plays a major role incausing limb defects.