Efecto de un manual educativo sobre conocimientos y actitudes en pacientes reumáticos y personal de salud / Impact of an educational handbook on knowledge and attitudes of rheumatic patients and health workers

To assess the impact of the educational manual Aches and Pain, on knowledge and attitudes of patients with chronic rheumatism and paramedics, using an instrument with 40 aseverations extracted from the manual, 77 patients and 42 paramedics were studied. The assessment instrument was responded before and after reading chapters of the manual, selected by the authors. Knowledge was quantified according to the number of correct answers. Adaptation to disease, optimism and self help capacity were the evalauted attitudes, using a five point scale. The study was completed by 48 patients and 42 paramedics. Knowledge improved from 19,9ñ5,3 to 25,6ñ6,15 correct answers in the former and from 23,6ñ4,9 to 30,3ñ5,5 in the latter (p<0,001), In patients there were improvements in the degree of adaptation to disease from 3,3ñ0,9 to 4,0ñ0,8 and in selfhelp capacity from 4,0ñ0,8 to 4,3ñ0,8; optimism did not improve significantly. In conclusion, the eductinal manual had an impact on knowledge and improved rheumatic patient's attitudes towards the disease

Caso clínico de agranulocitosis por clozapina / Clínical case of agranulocytosis by clozapin

Se presenta primer caso clínico de agranulocitosis inducida por Clozapina descrito en Chile. Se discuten algunos aspectos farmacológicos y hematológicos involucrados en esta complicación