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Korean Journal of Nephrology ; : 656-660, 1999.
Artigo em Coreano | WPRIM | ID: wpr-73441

RESUMO

A 63-year-old woman presented to the hospital with gross hematuria and acute renal failure. Kidney function deteriorated rapidly and progressively. A renal biopsy revealed segmental or circumferential crescents associated with linear deposits of immunoglobulin G, typical of anti-glomerular basement membrane disease. Both c-ANCA and anti-GBM antibody were detected in serum. She was treated with hemodialysis, plasmapheresis, high dose steroid and cyclophosphamide. However, she died 7 weeks after treatment because of pneumonia, without recovery of renal function. Serologic positivity of both ANCA and anti-GBM antibody are becoming more frequently recognized in rapidly progressive glomerulonephritis. The influence of c-ANCA on the clinical course of anti-GBM glomerulonephritis remains to be determined.


Assuntos
Feminino , Humanos , Pessoa de Meia-Idade , Injúria Renal Aguda , Doença Antimembrana Basal Glomerular , Anticorpos Anticitoplasma de Neutrófilos , Membrana Basal , Biópsia , Ciclofosfamida , Citoplasma , Glomerulonefrite , Hematúria , Imunoglobulina G , Rim , Plasmaferese , Pneumonia , Diálise Renal
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