Association of Anti N-methyl-D-aspartate (NMDA) Receptor Encephalitis with Chediak-Higashi Syndrome

Background: Neurological manifestations of Chediak-Higashi syndrome mainlyinclude peripheral neuropathy, ataxia, tremors, cranial nerve palsies, intellectual declineand seizures. Case Characteristics: A 2 years 10 month old girl with silvery hair syndromepresented with sub-acute onset behavioral issues, ataxia and multiple type abnormalmovements. Cerebrospinal fluid examination was positive for Anti NMDA receptorantibodies. Hair shaft examination and peripheral blood film findings were suggestive ofChediak Higashi syndrome. Message: Anti NMDA receptor encephalitis may beassociated with Chediak Higashi Syndrome.

Adenoma Malignum of Cervix – How Useful is Clinico- Radiological Diagnosis.

Adenoma malignum (AM) is a rare type of variant of cervical cancer. The entity remains silent because of common complaints of erratic menstrual cycles and leucorrhea in peri-menopausal age group of females. The imaging modalities play a great role in clinching the diagnosis before the final confirmation by histopathological examination. We present 60- years old post menopausal woman who reported to gynecology outpatient department with complaints of per vaginum bleeding and watery discharge of six months duration .She was evaluated by cross imaging modalities of ultrasound (US) ,color flow imaging(CFI) and magnetic resonance imaging (MRI) with working diagnosis of adenoma malignum of cervix..This was subsequently confirmed in histopathological examination. The importance of the case lies because of the early diagnosis by clinic-radiological evaluation in the light of poor prognosis and early dissemination of this entity.

Normal Functioning Pelvic Lump Kidney: Isolated Anomaly - Radiological Evaluation.

There is wide spectrum of Mullerian dysgenesis presenting in different ways. Routine ultrasound done of a child for pain abdomen discovered a pelvic mass supero-posterior to the urinary bladder. This was diagnosed as fused pelvic kidneys by various cross sectional imaging modalities like Computerized tomography (CT) and Magnetic resonance imaging (MRI).We present a 4-years male child who was diagnosed as a case of “lump kidneys” by plain sonography coupled with color flow imaging (CFI). The entity usually falls in the common group of VATER (vertebral, anorectal malformation, esophageal and renal) anomalies. But our present case was having isolated anomaly and this entity is of a great rarity as seen in literature.

Bilateral primary Non-Obstructive and Non-Refluxing Megaureter in Child: Diagnosis by Non-Radiation Imaging Modalities.

Bilateral megaureters can present as asymptomatic or symptomatic pathology in the form of flank pain or urinary tract infection. The entity can also be diagnosed in antenatal ultrasound scan. We present 12-year old male child who presented with both flank vague pain and was subjected to ultrasonography (US) and Magnetic Resonance Urography (MRU). There was no evidence of any reflux or obstruction noticed as uretero-vasical junctions were normal on both sides. He was diagnosed as a case of bilateral primary non obstructive megaureters. Base line study was carried out by non radiation modalities in our institute for further follow up.

Atypical iliac unicameral bone cyst – An incidental finding in MRI.

is no expansion of the bone with unicameral bone cysts but in our present case there was expansion making it atypical presentation. We present a 22-year male who underwent MRI for Lumbosacral spine for his vague low backache symptoms. There was incidental finding of bony lesion in left iliac bone which turned out to be simple bone cyst. The study of Lumbosacral spine was unremarkable.