1.
Indian J Physiol Pharmacol
; 1987 Apr-Jun; 31(2): 125-9
Artigo
em Inglês
| IMSEAR
| ID: sea-108515
RESUMO
Five of the substituted ethylenediamine amides (LMG I to V) were tested for various CNS attributes and for acute toxicity (24 hr mortality). All compounds were potent analgesics in various animal tests, LMG V being most potent. All reduced spontaneous activity of mice and potentiated ether anaesthesia. However, CAR was not altered and anti-MES were not pronounced in rats. Compounds appear to have a wide safety margin considering ED50 and LD50 in mice.