ChatGPT and medical research ethics: Debates and norms / 中华医学科研管理杂志

Objective:Analyze the ethical issues encountered or potential in the use of ChatGPT and explore its ethical norms and requirements.Methods:Based on the ethical perspective of medical scientific research, this paper analyzed the disputes existing in ChatGPT from the perspectives of morality, fairness, responsibility and supervision, and explored the reasons for the disputes from both subjective and objective aspects.Results:ChatGPT has ethical issues, fairness issues, accountability issues, and regulatory issues.Conclusions:Ethical issues in ChatGPT should be regulated from the perspectives of people-oriented, limiting monopoly, strengthening responsibility and insisting on development, to reduce potential risks and negative effects.

Multi-modal synergistic quantitative analysis and rehabilitation assessment of lower limbs for exoskeleton / 生物医学工程学杂志

In response to the problem that the traditional lower limb rehabilitation scale assessment method is time-consuming and difficult to use in exoskeleton rehabilitation training, this paper proposes a quantitative assessment method for lower limb walking ability based on lower limb exoskeleton robot training with multimodal synergistic information fusion. The method significantly improves the efficiency and reliability of the rehabilitation assessment process by introducing quantitative synergistic indicators fusing electrophysiological and kinematic level information. First, electromyographic and kinematic data of the lower extremity were collected from subjects trained to walk wearing an exoskeleton. Then, based on muscle synergy theory, a synergistic quantification algorithm was used to construct synergistic index features of electromyography and kinematics. Finally, the electrophysiological and kinematic level information was fused to build a modal feature fusion model and output the lower limb motor function score. The experimental results showed that the correlation coefficients of the constructed synergistic features of electromyography and kinematics with the clinical scale were 0.799 and 0.825, respectively. The results of the fused synergistic features in the K-nearest neighbor (KNN) model yielded higher correlation coefficients ( r = 0.921, P < 0.01). This method can modify the rehabilitation training mode of the exoskeleton robot according to the assessment results, which provides a basis for the synchronized assessment-training mode of "human in the loop" and provides a potential method for remote rehabilitation training and assessment of the lower extremity.

Human muscle fatigue monitoring method and its application for exoskeleton interactive control / 生物医学工程学杂志

Aiming at the human-computer interaction problem during the movement of the rehabilitation exoskeleton robot, this paper proposes an adaptive human-computer interaction control method based on real-time monitoring of human muscle state. Considering the efficiency of patient health monitoring and rehabilitation training, a new fatigue assessment algorithm was proposed. The method fully combined the human neuromuscular model, and used the relationship between the model parameter changes and the muscle state to achieve the classification of muscle fatigue state on the premise of ensuring the accuracy of the fatigue trend. In order to ensure the safety of human-computer interaction, a variable impedance control algorithm with this algorithm as the supervision link was proposed. On the basis of not adding redundant sensors, the evaluation algorithm was used as the perceptual decision-making link of the control system to monitor the muscle state in real time and carry out the robot control of fault-tolerant mechanism decision-making, so as to achieve the purpose of improving wearing comfort and improving the efficiency of rehabilitation training. Experiments show that the proposed human-computer interaction control method is effective and universal, and has broad application prospects.

Active response to population aging with scientific and technological innovation in China / 中华老年医学杂志

The situation of population aging is grim.And scientific and technological innovation is an important strategic support means to solve the problem of population aging.President Xi Jinping has put forward the guiding ideology of "Four Facing" of scientific and technological innovation, pointing out the direction of using science and technology to support the high-quality development of the aging cause and to realize healthy aging.The scientific and technological innovation of population aging has always been highly integrated with exploring international science frontiers, serving main economic sectors, meeting major national needs and safeguarding people's life and health.This paper elaborates on the deep integration between the aging population and the "four facing" of scientific and technological innovation, in order to better construct a new development pattern, and for science to help actively cope with the smooth implementation of the national strategy of population aging.

Promoting the information management of hospital ethics review by establishing an information system / 中华医学科研管理杂志

Objective:Through the establishment of a tertiary hospital ethics review information system, the information management of ethics review is carried out, thereby improving the quality and efficiency of ethics review.Methods:Four steps that including status quo analysis and problem identifying, corrective action plan making, outcome monitoring, as well as experience analysis were conducted, according to which a full-chain ethical review information system was developed. This system has certain characteristics such as well-featured functions, reasonable structure and user friendly, which fulfilled the expectation of the information management of review work.Results:The updated ethics review information system provides much stronger support for ethics review management and also improves its efficiency.Conclusions:The information system makes the management of ethics review more efficient, standardized and well-organised.

The international experiences of Investigator-initiated Clinical Trials and implications / 中华医学科研管理杂志

Objective:To introduce the experience of international Investigator- initiated Clinical Trials (IIT), provide suggestions for the construction of IIT management system in China. Methods:Applying the literature review research methodologies to analyze the document materials, five aspects including the funding source, technical support, personnel training, management mechanism and policy assurance were analyzed.Comparison was conducted to identify possible problems existed in Chinese IIT, and further explore possible lessons that we can learn in Chinese context.Results:Identified problems of Chinese IIT include insufficient funds, unsound scientific research design, imperfect data information system, lack of standard training for researchers, as well as the urgent need for more optimized whole-process management, quality control, and policy support.Conclusions:Suggested series of measurements that including expand the funding sources, improve the construction of scientific steering committee, improve the construction of data information platform at the national level, standardize the training of researchers, and update the operation mechanism and also the regulatory requirement are proposed to enhance the IIT research quality, as well as the IIT management.

Study on the current situation and countermeasures of human genetic resources management in a tertiary hospital / 中华医学科研管理杂志

Objective:To analyze the current situation of human genetic resources management in a tertiary hospital, and propose improvement suggestions for the management of human genetic resources in tertiary hospitals.Methods:According to the review of laws and regulations of human genetic resources management in China, analyze the current situation, challenges and management suggestions of human genetic resources management in this particular tertiary hospital, and further management suggestions are proposed.Results:Main problems were identified in the tertiary hospital, including the knowledge of researchers needs to be improved, and due to lack of supervision and management on process of human genetic resources projects, the management of investigator initiated clinical trials needs to be further strengthened.Conclusions:The tertiary hospital needs to strengthen the researcher training on the management of human genetic resources, establish the whole-process supervision of human genetic resources project and pay more attention to the management of investigator initiated clinical trials.

The development and consideration of a framework for a Chinese elderly health standards system / 中华老年医学杂志

Objective:To develop a framework for a national system of elderly health standards in response to population aging in China and to meet the need for health service standards for elderly care, thus providing a roadmap for the development of elderly health standards.Methods:Preliminary indicators for a framework of a Chinese elderly health standards system were established by literature review and expert consultations.Using the Delphi method, we invited 23 experts to form a consultation panel.After two rounds of expert consultations, the preliminary framework was updated and the weight of each indicator was calculated by using the analytic hierarchy process.Results:A framework of the Chinese elderly health standards system was established after two rounds of expert consultations.The expert authority coefficient was 0.847.The framework proposed four primary indicators, including basic health standards, medical service standards, public health standards and social support standards, for the elderly, with a weight of 0.204, 0.346, 0.260 and 0.189 for each indicator.There were 22 secondary indicators, including standardized terminologies, medical services, health education, geriatrics personnel training, etc., for elderly care.Conclusions:Our research has generated a preliminary framework of an elderly health standards system that incorporates China's specific issues, takes into consideration of the needs of various parties and covers many relevant aspects.It will provide the basis for decision-making in the elderly health standardization process in China and safeguard the implementation of the Healthy China strategy.

Analysis on the layout of China’s emergency research projects during the public health emergency of COVID-19 / 中华医学科研管理杂志

Objective:To explore the main layout and countermeasures of Scientific research projects during the public health emergency of COVID-19.Methods:Literature investigation method is applied to collect information of scientific research and emergency research projects of COVID-19 funded since January 20th by different entities including national, provincial and municipal administrative departments, public health agencies, research institutes, universities and industries.Results:Along with priorities identified for the emergency response and key research agendas, the national science and technology authorities at all levels and scientific research institutions have deployed a series of new science and technology projects, as well as a number of supporting policies and measures.Conclusions:In the campaign of science and technology to deal with COVID-19, the leadership of Chinese government and their coordination with local agencies facilitated quick response in both R&D investment and supporting policies. Periodical achievement is recognized so far, and with the continuous development and in-depth research, the related scientific research results will be gathered into the core force of epidemic prevention. Moreover, it will improve China's capacity to deal with health emergencies and the level of medical health innovation, and better protect the health of the people.

Conduct of clinical trials under primary response to major public health emergencies in tertiary hospital / 中华医学科研管理杂志

Objective:Understand the status of clinical trials under primary response to major public health emergencies (COVID-19 epidemic) in tertiary hospital.Methods:The electronic questionnaire was used to collect information of clinical trials, including these have been approved by ethical committee, still in the recruiting process or in the following up of enrolled human subject. The questionnaire included basic information, measures adopted by the trials and experiences for dealing with the common problems associated conducting clinical trials during the pandemic.Results:A total of 198 questionnaires were returned, including 92 trials that have not yet recruited subjects and 106 trails that have recruited subjects. 59.15% of clinical trials that haven’t been initiated decide to postpone the starting date and 76.19% of clinical trials that haven’t recruited subjects decided to postpone subject recruitment. 36.87% of clinical trials made contingency plan or other similar documents. For those trials that have started to recruit subjects, 5.66% clinical trials prolonged follow-up time window, 61.32% of clinical trials followed up subjects and 51.89% of clinical trials provided instructions to subjects through remote technology, 51.89% of clinical trials allowed subjects to do lab tests in nearby hospitals. 38.68% clinical trials mailed drugs to subjects under guaranteed transportation conditions. For clinical trials that required subjects come to hospital to follow up, 92% of clinical trials will check whether subjects had been to high risk area and measure body temperature when follow-up. For clinical trials involving delayed follow-up, 46.97% of clinical trials would recorded and reported protocol deviation, 6.07% of clinical trials would not report or have not yet decided whether to report protocol deviation.Conclusions:Sponsors and hospitals conducting clinical trials abide by the basic principles of epidemic prevention and take corresponding measures according to local conducting, focusing on the protection of subjects. Most clinical trials comply with the Good Clinical Practice and ethical principles to ensure that clinical trial were carried out as effectively as possible.

A study of researchers’ recognition of research integrity and scientific misconduct in the workplace in Tertiary Hospital / 中华医学科研管理杂志

Objective:The study aimed to determine researchers’ awareness on research integrity and scientific misconduct in the workplace in Tertiary Hospital.Methods:The electronic questionnaire was distributed to 278 researchers in 3 Tertiary Hospitals. Information collected included the demographic characteristics, the awareness of research integrity, attitude to scientific misconduct, occurrence of misconduct among colleagues and possible intentions of misconduct behaviors.Results:Questionnaires of 217 researchers were analyzed in this paper. Less than 20% of respondents were familiar with the definition of research integrity, fabrication, falsification, and so on. Regarding attitude towards scientific misconduct, less than 50% of respondents would like to stop the behavior, report to regulatory authorities if scientific misconduct was identified. Less than 50% of respondents agreed that all the authors should be punished if the paper was involved in scientific misconduct. 49.31% of researchers admitted that their colleagues had committed at least one of the nine listed forms of scientific misconduct. 37.33% of researchers admitted that their colleagues had admitted at least one of the FFP behaviors. Inappropriate authorship was the most common issue of scientific misconduct according to the study findings. Statistical analysis showed that the cognition of research integrity was negatively correlated with scientific misconduct intention.Conclusions:Researchers’ awareness on research integrity and scientific misconduct in workplace in Tertiary hospital was worrisome. A multi-faceted approach towards the issue will be required.

The construction of scientific research evaluation index system based on STEM for the tertiary class A general hospital / 中华医学科研管理杂志

Objective:To build a scientifically applicable scientific research evaluation system based on the Science and Technology Evaluation Metrics (STEM) of Chinese hospitals.Methods:Twenty-four experts were invited to form an expert advisory group, scientific research evaluation indicators were collected according to literature review, panel discussion and expert consultation. Use Delphi method to carry out two rounds of expert consultation, calculate the authority level and positive factor of experts, and use AHP to calculate the weight of each indicator.Results:The experts invited for consultation had a high positive coefficient and a high degree of expert authority, and finally, a scientific research evaluation index system including 3 first-level indicators, 10 second-level indicators and 24 third-level indicators was established.Conclusions:The research based on STEM has developed an evaluation system well combined quantity and quality from three dimensions, including scientific research input, scientific research output and scientific research influence. Taking into full consideration of the regulatory requirement of clinical trials and the research administration of research achievements transformation, this research established an evaluation system and management model applicable to the Tertiary class A general hospitals, provided reference value for the development of the hospital's scientific research.

A survey of tertiary hospital new researchers’ awareness and attitude on scientific integrity / 中华医学科研管理杂志

Objective:Understand the perceptions of research integrity and their attitudes to related integrity violations among newly recruited researchers in a tertiary hospital.Methods:The electronic questionnaire was distributed to a WeChat group of 123 newly recruited researchers in a tertiary hospital in 2018. The questionnaire included the demographic characteristics, the awareness of research integrity and attitude towards behaviors that violate research integrity.Results:The total number of respondents was 87 and 45.98% respondents received research integrity training. Less than 50% of respondents were familiar with the regulatory requirement of research integrity, the definition of research integrity, fabrication, falsification, plagiarism and other common problems violating research integrity. Regarding attitude towards scientific misconduct, most investigators (82.76%~90.8%) thought it incorrect. 64.37% of investigators would like to report to regulatory authorities if they found scientific misconduct. If the researchers strongly violated research integrity, 80.46%~81.61% of respondents voted for suspending his or her promotion, suspending his or her application for being a mentor and 58.62% of respondents voted for being banned for conducting any research forever. Receiving education of research integrity is an independent influence factor of awareness of fabrication, falsification and plagiarism (FFP).Conclusions:The proportion of newly recruited researchers receiving research integrity training in tertiary hospital is not big and most researchers don't know much about research integrity. Their attitudes to academic misconduct need to be further strengthened. Various measures are urgently needed to carry out to improve the integrity awareness and attitude of newly recruited researchers in tertiary hospitals.

Analysis on the layout of China’s emergency research projects during the public health emergency of COVID-19 / 中华医学科研管理杂志

Objective@#To explore the main layout and countermeasures of Scientific research projects during the public health emergency of COVID-19.@*Methods@#Literature investigation method is applied to collect information of scientific research and emergency research projects of COVID-19 funded since January 20th by different entities including national, provincial and municipal administrative departments, public health agencies, research institutes, universities and industries.@*Results@#Along with priorities identified for the emergency response and key research agendas, the national science and technology authorities at all levels and scientific research institutions have deployed a series of new science and technology projects, as well as a number of supporting policies and measures.@*Conclusions@#In the campaign of science and technology to deal with COVID-19, the leadership of Chinese government and their coordination with local agencies facilitated quick response in both R&D investment and supporting policies. Periodical achievement is recognized so far, and with the continuous development and in-depth research, the related scientific research results will be gathered into the core force of epidemic prevention. Moreover, it will improve China's capacity to deal with health emergencies and the level of medical health innovation, and better protect the health of the people.

Effect of Chaijie Yiganxian on Hepatic Fibrosis Induced by Thioacetamide in Rats / 中国实验方剂学杂志

Objective: To research the effect of traditional Chinese medicine compound Chaijie Yiganxian (CJYGX) on the hepatic fibrosis in rats and explore the mechanism. Method: Totally 60 SD rats were randomly divided into normal group, model group, positive group (Biejia Jianwan), and low, medium and high-dose CJYGX groups. Except for the normal group, the remaining five groups were involved in establishing the hepatic fibrosis model through the intraperitoneal injection of thioacetamide (TAA). Fourth weeks after modeling, the positive group was given Biejiajian pill (1 g·kg-1·d-1), and high, medium and low-dose CJYGX groups were given CJYGX(7.96, 3.98, 1.99 g·kg-1·d-1), respectively. The model group was given normal saline once a day for 5 weeks. 24 h after the last intragastric administration with chloral hydrate, the rats were anesthetized slightly. Serum and liver tissues were collected. The liver wet weight was weighed electronically, and the liver index was calculated. Liver function indexes[alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP)] and serum markers[laminin (LN), hyaluronidase (HA), Ⅳ collagen (CⅣ), procollagen Ⅲ (PCⅢ)] of hepatic fibrosis were detected by enzyme linked immunosorbent assay (ELISA). The degree of hepatic fibrosis by Masson stain, mRNA expressions of transforming growth factor-β1 (TGF-β1), Smad2, Smad3, Smad4, Smad7 were detected by Real-time fluorescence quantitative polymerase chain reaction (Real-time PCR), and protein expression levels of platelet derived growth factor (PDGF), TGF-β1 and α-smooth muscle actin (α-SMA) were detected by immunohistochemical or Western blot. Result: Compared with the blank group, the model group liver index was significantly increased; the contents of ALP, AST and ALT were significantly increased; the liver fibrosis indexes LN, HA, Ⅳ-C, PCⅢ and HYP were significantly increased; the degree of liver fibrosis was significantly increased in Masson tissue; the mRNA expressions of TGF-β1, Smad2, Smad3, Smad4 were significantly increased; and the Smad7 mRNA expression was significantly decreased. The protein expressions of TGF-β1, PDGF and α-SMA increased significantly (Pβ1, Smad2, Smad3, Smad4 and up-regulate mRNA expression of Smad7.Immunohistochemical and Western blot analysis show that, compared with model group, CJYGX could significantly reduce the protein expressions of TGF-β1, PDGF and α-SMA (PPConclusion: Traditional Chinese medicine compound CJYGX may protect TAA-induced hepatic fibrosis injury by interfering with TGF-β1/Smad signaling pathway.

Investigation and analysis of scientific research multidisciplinary team collaboration intention among young researchers in a Grade-A Hospital / 中华医学科研管理杂志

Objective To understand the intention and needs of young researchers in a Grade-A Hospital to carry out the Multidisciplinary Team (MDT),to provide references for hospital to condense the direction of scientific research,set up Multi-disciplinary resear Teams,as well as conduct innovative medical research.Methods A questionnaire survey was conducted among 196 young researchers under 45 years old in Grade-A Hospital,collected data were analyzed statistically.Results The total understanding and comparative understanding of the MDT model among the respondents was 52.05 ％.The differences in the MDT pattern recognition were statistically significant(P＜0.05) in different ages,titles and departments,and nearly 100 ％ of the respondents expressed their willingness to participate in the research MDT.68.37％ believed that cooperation should be carried out according to the research direction.66.63％ believed that the distribution of results should be based on the uniform norms issued by hospitals,and the allocation plan should be refined according to the project.61.73％ believed that a consistent cooperative goal was important to set up MDT,and 46.43％ emphasis on the role of academic leader in organizing and leading MDT.Conclusions The enthusiasm of young researchers in a Grade-A Hospital is very high,and there isstrong willingness to cooperate with MDT.Hospitals should bring in more effective organization mode of MDT research collaboration and incentive measures to future condense the direction of scientific research,focus on direction,solve scientific problems in depth,and ultimately promote the substantiality formation of multidisciplinary research collaboration and output.

Whether Fire-needle Therapy Benefits Plaque Psoriasis: A Multicenter, Randomized, and Controlled Trial / 中国结合医学杂志

OBJECTIVE@#To observe the clinical effectiveness and safety of fire-needle therapy, an external approach of Chinese medicine in treating plaque psoriasis.@*METHODS@#This study was a two-parallel-arm randomized controlled trial. A total of 151 participants with plaque psoriasis were randomly assigned to the fire-needle therapy group (treatment group, 76 cases) or the control group (75 cases) at a 1:1 allocation ratio using SAS software. All participants received Oral Huoxue Jiedu Decoction (, HXJDD) and applied externally vaseline cream twice a day. Participants in the treatment group received fire-needle therapy once weekly for 4 weeks plus HXJDD and vaseline cream applied the same as the control group. The primary outcome measure was Psoriasis Area and Severity Index (PASI) score, and the secondary outcomes were Dermatology Life Quality Index (DLQL), and Hamilton Anxiety Rating Scale (HAMA), as well as Chinese medicine (CM) syndrome score and photos of target lesions. The indices were evaluated before and after treatment.@*RESULTS@#Sixty-eight patients in each group completed the study. The treatment group has not yet achieved significant improvement in PASI score (P>0.05) compared to the control group. However, significant differences were found between the two groups in relieving CM syndrome (P<0.05) and improving quality of life (P<0.05).@*CONCLUSION@#Fire-needle appears to be safe and may have benefit for psoriasis, the short-term treatment and small sample size limit the conclusions of this study. Further rigorous randomized controlled trials with longer treatment are recommended.

Dog-transmitted Rabies in Beijing, China / 生物医学与环境科学（英文）

Rabies remains a continuous threat to public health in Beijing. In this study, a total of 224 brain tissues were collected from suspected infected stray dogs within Beijing between January 2015 and December 2016. Among them, total of 67 samples were diagnosed positive for rabies. In the phylogenetic analysis, rabies in Beijing is currently a relatively independent public health issue originating from local rabid dogs apart from the imported cases from elsewhere in the country. Because vaccination of unregistered dogs against rabies is still neglected in Beijing and other regions of China, national and local authorities should play central roles in all related aspects, such as development of policies, engagement of stakeholders for public and professional education, entire vaccination process, and animal management.

Case-control study of therapeutic effects between extreme lateral interbody fusion and conventional posterior operation for the treatment of upper lumbar disc herniation / 中国骨伤

<p><b>OBJECTIVE</b>To evaluate the clinical outcomes between extreme lateral interbody fusion and conventional posterior operation in the treatment of upper lumbar disc herniation.</p><p><b>METHODS</b>Among 60 patients with upper lumbar disc herniation were treated with extreme lateral interbody fusion(XLIF) or conventional posterior operation from June 2010 to December 2014, 30 patients(19 males and 11 females) were treated with XLIF (XLIF group); and the other 30 patients(17 males and 13 females) were treated with conventional posterior operation (conventional group). In XLIF group, the lesions occurred at T₁₂L₁ segments in 2 patients, at L₁,₂ segments in 6 patients, at L₂,₃ segments in 10 patients, and at L₃,₄ segment in 12 patients. In conventional group, the lesions occurred at T₁₂L₁ segments in 1 patient, at L₁,₂ segments in 6 patients, at L₂,₃ segments in 8 patients, and at L₃,₄ segment in 15 patients. Operative incision lengths, time, blood loss, postoperative draining volume, hospital stays were recorded. Pre-and post-operative visual analogue score(VAS) and Japanese Orthopedic Association(JOA) were compared between two groups. According to the image data, the intervertebral fusion device was observed to be displaced and the rate of interbody fusion was analyzed.</p><p><b>RESULTS</b>All the patients were followed up, and the duration ranged from 12 to 48 months, with an average of 29 months. The complications included 2 femoral nerve damage in XLIF group (postoperative recovery within 3 months) and superficial incision infection in conventional group(cured by anti-infection). There were no patients with cerebrospinal fluid leakage(CSFL), cauda equina injuries or functional deterioration in the nerve root of lower limbs. In the XLIF group: the operative time was (65.6±20.5) minutes, blood loss was (48.8±15.3) ml, postoperative draining volume was 0 ml. In the conventional group: the operative time was (135.2±33.9) minutes, blood loss was (260.3±125.7) ml, postoperative draining volume was (207.1±50.2) ml. The operative time, blood loss, postoperative draining volume in XLIF group were less than those in the conventional group(<0.05). The JOA and VAS score were significantly improved in both groups during the follow-up period compared with those before operation(<0.05). But the difference of the JOA and VAS score between the two groups 1, 6, and 24 months after surgery had not significant differences(>0.05). There were no significant differences in the fusion rate between the two groups 6 and 12 months after operation(>0.05).</p><p><b>CONCLUSIONS</b>The XLIF fusion for the treatment of upper lumbar disc herniation has several advantages such as minimal invasive, stable vertebral plate, less complications and postoperative fusion rate, which has a better clinical effect.</p>

Important role of Rho/ROCK2 pathway in the development of Alzheimer’s disease / 国际药学研究杂志

Rho/ROCK pathway is a ubiquitous singling pathway in organisms, and is involved in many biological processes. In the brain of Alzheimer’s patients, the activities of Rho and Rho associated coiled coil forming protein kinase(ROCK)are up-regulated, which is accompanied by the elevation of Aβ42 level, and the abnormal change of the morphology and function of neuronal processes, suggesting that the occurrence and development of Alzheimer’s disease(AD)is associafed with the overexpression and excessive activation of Rho or ROCK. Rho/ROCK2 pathway is considered a target pathway for the prevention and treatment of AD, and Rho or ROCK2 also becomes an important target for AD drug development. Numerous studies have revealed that suppressing the expression or decreasing the activity of Rho or ROCK2 can reduce Aβ42-induced neurotoxicity, protect neurons, and slow down the occurrence and de velopment of AD. Therefore, specific inhibition of ROCK2 has an important significance for the repair of central nervous system damage and the treatment of AD. This article reviews several effects of Rho/ROCK2 pathway on the development of AD.