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OBJECTIVE@#To characterize the hemodynamic changes of chronic congestive heart failure(CHF) model induced by rapid right ventricular pacing after myocardial infarction in awake Beagle dogs.@*METHODS@#Five healthy adult male Beagle dogs were prepared for surgery. After the probes for measurement and the pacing leads were implanted, the left anterior descending artery was ligated during the surgery to induce myocardial infarction in the anterior wall of the left ventricle close to the apex. Six weeks after the surgery, rapid right ventricular pacing was initiated at the rate of 220 to 260 beats per minute for 4 weeks to induce CHF. Echocardiography was performed before the surgery. Both echocardiography and hemodynamic measurement were carried out before the rapid pacing and 4 weeks after the rapid pacing when the Beagle dogs were awake.@*RESULTS@#There was no significant difference in left ventricle end diastolic diameter (LVEDD), left ventricle ejective fraction (LVEF), and fractional shortening (FS) between pre-operation and pre-pacing. LVEDD [(44.71+/-3.35) vs. (38.01+/-1.54) mm] and left ventricle end diastolic pressure (LVEDP) [(25.63+/-1.86) vs. (10.58+/-1.23) mmHg] at 4 weeks after pacing significantly increased compared with the pre-pacing data(P<0.05). LVEF, FS, and LV dp/dt max were significantly declined (P<0.01).@*CONCLUSION@#Left ventricle remodeling and hemodynamic changes in the Beagle dog CHF models produced by rapid right ventricular pacing after myocardial infarction are similar to the changes observed in CHF of human beings.
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Animais , Cães , Masculino , Modelos Animais de Doenças , Insuficiência Cardíaca , Hemodinâmica , FisiologiaRESUMO
Acute massive pulmonary thromboembolism after pneumonectomy usually results in death if not diagnosed early and treated aggressively.It was a case of acute embolism in the main pulmonary ar-tery with thrombus following right pulmonary wedge resection.Diagnosis was made clinically and with computerized tomography before emergency surgery.Thromboembolectomy was successfully performed on cardiopulmonary bypass and the patient was subsequently discharged home after uneventful recovery.Al-though the patient had no previous history of thrombosis,he took high dose of warfarin for anticoagulating postoperatively,which suggested that the patient with pulmonary embolism attack may be associated with the hypercoagulable state of his own.
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0.05). However, we found that the proportions of low Qm (5) in the patients over 60 years were significantly higher than those in the patients younger than 60. [For low Qm, IMA: 13% (10/75) vs 2% (1/46), and GSV: 13% (33/259) vs 6% (7/123), ?2=4.296 and 4.422, P
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Objective To evaluate the efficacy of endovascular stent-graft placement for the treatment of Debakey Ⅲ type aortic dissection. Methods From June 2001 to July 2006, 31 patients with Debakey Ⅲ type aortic dissection were diagnosed by contrast-enhanced CT scan. Vascular access was obtained through the right or left femoral artery after arteriotomy and stent-graft was deployed into the true lumen to occlude the primary entry tear. Immediate aortography was performed after the procedure and the follow-up data of CT scan were evaluated. Results Stent-graft deployment was successfully performed in all the patients. Immediate aortography after the procedure showed no leakage in 27 patients and minor leakage in 4. After the operation, one patient showed paraplegia, and one developed left arm ischemia. No stent movement or organ ischemia was found at the early postoperative stage in the other patients. Six months after the operation, in all the 31 patients, contrast-enhanced CT scan showed the disappearance of the false lumen and thrombosis at the level of the stent; and the minor leakage of was improved in the 4 patients. Four years after the operation, one patient developed severe internal leakage at the approximal end of the stent, and was treated by thoracotomy. Conclusions Endovascular stent-graft placement is effective for the treatment of Debakey Ⅲ type aortic dissection. However, further studies are needed to evaluate its long-term outcomes.
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0.05]. Moreover, the Qm and PI of the grafted anterior descending, circumflex, and right coronary arteries were similar between the two groups.Conclusions No significant difference exists in the graft blood flow between OPCABG and CCABG groups.
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5) receiving cardiopulmonary coronary artery bypass grafting(CCAB) during the same period was reviewed as control group(CCAB Group).The preoperative risk factors,operation parameters,and postoperative outcomes between the two groups were compared for statistical analysis.Results The EuroSCORE value of the OPCAB Group and the CCAB Group was 9.0?2.6 and 8.3?2.1,respectively(t=2.016,P=0.045). The number of grafts in the OPCAB Group was less than that in the CCAB Group(3.2?0.9 vs 3.8?0.9;t=-4.267,P=0.000).The postoperative levels of creatine kinase(CK) and creatine kinase myocardial band(CK-MB) were significantly lower in the OPCAB Group [570(61～8246) U/L and 20(1～282) U/L] than the CCAB Group [870(246～8155) U/L and 55(12～300) U/L](Z=-3.648 and-5.767,P=0.000).The blood transfusion in the OPCAB Group was significantly less than that in the CCAB Group(775?693 ml vs 1088?712 ml;t=-2.887,P=0.004).There was no statistical difference in postoperative complications between the two groups.The mortality is 3.5%(4/113) in the OPCAB Group and 6.6%(5/76) in the CCAB Group,without statistical difference(?2=0.925,P=0.336).Conclusions OPCAB is safe and effective in high risk patients.Different operation methods should be used for patients with different risks.