Anti inflammatory activity of indanyltetrazole derivatives

A number of indanyl tetrazolederivatives namely 5-[6'-chloroindan-1'-yl]tetrazole [CIT], 5-[6'-bromoindan-1'-yl]tetrazole [BIT], 5-[6'-chloroindan-1'-yl]methyltetrazole [CIMT], 5-[6'-bromoindan-1'-yl]methyl-tetrazole [BIMT] were evaluated for the anti-inflammatory activity in carragennan induced rat paw edema in Swiss albino Wister rats for 24-hour period at the dose of 100 mg/kg of body weight by intraperitoneal route where phenylbutazone [PBZ] was used as the standard. All of these compounds exhibited inhibition on rat paw edema with peak actions observed following 3 hours after administration. Moreover, compounds CIMT and BIMT were further evaluated at dose of 50 mg/kg of body weight. Among the compounds, CIMT showed higher activity than others and was very close to standard phenylbutazone

Hepatoprotective activity of Phyllanthus reticulatus

Two partially purified organic fractions designated by PR1 and PR2 of the fat free ethanol [95%] extract of aerial parts of Phyllanthus reticulatus were tested for the hepatoprotective activity in rats against CCl[4]-induced liver damage. The rats receiving the fractions showed promising hepatoprotective activity as evident from significant changes of pentobarbital-induced sleeping time, changes in serum levels of sGPT, sGOT, sALP and bilirubin and also from histopathological changes as compared to CCl[4]-intoxicated rats