Treatment of behavioral disorders by risperidone in children with autism / 中国当代儿科杂志

<p><b>OBJECTIVE</b>To study the effect of risperidone treatment on behavioral disorders in children with autism.</p><p><b>METHODS</b>Forty children with behavioral disorders (aged from 5 to 12 years) were treated with risperidone for 8 weeks. The behavioral symptoms were evaluated by the Clinical Global Impression (CGI) and the Autism Treatment Evaluation Checklist (ATEC) before and after the treatment. The adverse events related to risperidone treatment were observed.</p><p><b>RESULTS</b>The score of severity of illness and the ATEC total scores were significantly reduced 8 weeks after risperidone treatment. Besides the social intercourse ability, great improvements have been shown on the verbal communication, apperception and behavioural symptoms by the ATEC. No severe adverse events related to risperidone treatment were observed.</p><p><b>CONCLUSIONS</b>Risperidone can significantly improve the behavioral disorders in children with autism and is well-tolerated.</p>

Influential factors for the sensory integration training effects in children with autism / 中国当代儿科杂志

<p><b>OBJECTIVE</b>There are many factors affecting the sensory integration training (SIT) effects in children with autism. This study explored the influential factors for SIT effects in the aspect of the model of sensory processing.</p><p><b>METHODS</b>Ninety-three autistic children aged 1.8-8.3 years were evaluated by the autism behavior checklist (ABC) and the Dunn's model of sensory processing. The SIT effects were evaluated by the sensory integrative schedule. The effects of sex, age, ABC scores and the Dunn's model of sensory processing were investigated by logistic regression analysis.</p><p><b>RESULTS</b>Logistic regression analysis showed that ABC scores (Wald=6.768, <0.01) and the Dunn's model of sensory processing (Wald=13.549, <0.01) were influential factors for the SIT effects. The Dunn's model of sensory processing was shown as a more important influential factor. Sex (Wald=1.549, >0.05) and age (Wald=0.010, >0.05) were not related to the STT effects.</p><p><b>CONCLUSIONS</b>The Dunn's model of sensory processing is a major influential factor for the SIT effects in children with autism.</p>