RESUMO
Objective To explore the influence of the fetal microchemirism in the thyroid tissue on the Graves' disease(GD) animal model.Methods Mice in experimental group were injected with Ad-TSH289(5?108IU) to construct the GD animal model,and when the immunization was over,the experimental group was randomly divided into three parts again: two groups were mated with male mice until two weeks of pregnancy or two weeks post-partum while the other group was simple immunized with Ad-TSH289 only.SRY was tested by real-time PCR.Thyroid tissue was stained with HE for pathological examination.Results Histological examination of the thyroid gland revealed that 61.8% of simple immunized mice had goiter,the success rate of GD animal model was 38.5% in pregnancy group,but 76.9% in postpartum groups(P