Formulation and Evaluation of Microemulsion Based Topical Hydrogel Containing Lornoxicam.

The objective of present study was to formulate hydrogel thickened Lornoxicam transdermal formulation. Eutectic mixture of camphor and menthol was chosen as oily phase (maximum 10%), solvent for Lornoxicam and powerful penetration enhancer. Tween 80, ethanol and Carbopol 934p, HPMC K-15M and Xanthan gum were selected as surfactant, co-surfactant and hydrogel thickening agent respectively. Ternary phase diagrams were constructed to obtain the concentration range of oil phase, surfactant and co-surfactant for microemulsion formulation. Hydrogel thickened microemulsions were characterized for pH, viscosity, spreadability, in vitro drug transport study with excised rat skins and invivo anti inflammatory activity. The average drug transport rate of optimized hydrogel thickened microemulsion containing 1 % w/w Lornoxicam, 10 % w/w oily phase of camphor and menthol, 30 % w/w tween 80, ethanol (2:1), 57 % w/w water, 1.5 % w/w Carbopol 934p and 0.5 % w/w Triethanolamine through rat skin was 2.02 μg/cm2/h . The percentage in vitro drug release of optimized hydrogel thickened microemulsion was 78.91 %. pH, viscosity and spreadability of optimizes batch was 6.4, 5291 cps and 5.98 gcm/sec.

Formulation and Evaluation of Repaglinide Buccal Tablet: Ex Vivo Bioadhesion Study and Ex Vivo Permeability Study.

The present work was performed to develop and evaluate buccal tablet containing antidiabetic drug (Repaglinide). Ethyl cellulose was used as backing membrane and Carbopol 934p, Polyox wsr N-80 NF, HEC and HPC was used as bucco adhesive polymer. Aspartame was used as sweetener. Thickness, Hardness, weight variation and drug uniformity were investigated. The tablet formulations were also subjected to drug release in 250ml 6.8 phosphate buffer. Ex vivo bioadhesion, retention time and permeation through porcine buccal mucosa membrane. Effects of different bucco adhesive polymer were evaluated on release and bioadhesion, retention time and permeation of drugs. F5 formulations showed maximum amounts of drugs release (87.18%) at the end of 10 h dissolution study. F5 also showed maximum bioadheion (0.0754N) and the resident time of F5 formulation was 9.2 h. It shows 41.52% drug release after 10 h permeation study through porcine buccal mucosa mounted in Franz cell. The tablet also found stable in human saliva after 10hr. The tablet was not showed any type of physical changes after the completion of 10 h. The results of the study suggested that new buccal tablet formulations of combined bucco adhesive polymers can be suitably developed as an alternate to conventional dosage forms.