A Case of Human Infestation of Canine Scabies / 대한피부과학회지

Transmission of animal scabies to human is probably rare because of the relative host specificity of the mites. However, recurrent exposure to animal scabies mites can produce troublesome and diagnostically puzzling lesions. We report herein on a human infestation of canine scabies and this occurred in a 26-year-old male who presented with a 4-month history of severe pruritic skin lesions. His puppy was diagnosed with scabies infestation by a veterinarian two months previously. Since that time, he no longer raised the puppy. Microscopic examination of a mineral oil preparation after scraping the papules revealed a mite. He was diagnosed with canine scabies.

The Expression of Melanin Pigment and Melanocytes in Basal Cell Carcinoma of Sun-Exposed and Non-Exposed Areas / 대한피부과학회지

BACKGROUND: Basal cell carcinomas (BCCs) are the most commonly encountered skin cancers. In Asian patients, marked pigmentation is frequently observed in BCC lesions. Although many authors have documented the incidence of pigmentation in BCCs, its pathogenesis, especially mechanisms associated with sun exposure, have rarely been studied. OBJECTIVE: This study aimed to evaluate the expression pattern of melanin pigments and melanocytes in BCCs of sun-exposed and non-exposed areas of skin and investigate the association of ultraviolet radiation with the pigmentation process of BCCs. METHODS: We examined 30 cases of BCCs occurring in sun-exposed areas of skin, and 8 cases of non-exposed areas of skin, using the Fontana-Masson and MART-1 immunohistochemical methods, with paraffin-embedded sections. RESULTS: Most melanin was found in tumor nests and surrounding dermal stroma (53.0%) and was superficially (60.0%) or fairly uniformly (33.3%) distributed in BCCs of sun-exposed areas. In all BCCs of sun-exposed areas, melanocytes were found in tumor nodules, not in dermal stroma. When the staining level of BCCs occurring in sun-exposed areas was compared with that of non-exposed areas, BCCs of sun-exposed areas showed significantly increased expression in Fontana-Masson (p<0.001, chi-square test) and MART-1 (7.75+/-4.77 vs 2.08+/-2.68; p=0.001, Mann-Whitney U-test) stains. CONCLUSION: Our immunohistochemical staining of BCC specimens revealed that ultraviolet radiation is closely associated with the pigmentation process of BCCs. Although accurate mechanisms are not yet established, these findings suggest a basis for the idea that complex phenomenon lead to hyperpigmentation in BCC.

The Expression of Melanin Pigment and Melanocytes in Basal Cell Carcinoma of Sun-Exposed and Non-Exposed Areas / 대한피부과학회지

BACKGROUND: Basal cell carcinomas (BCCs) are the most commonly encountered skin cancers. In Asian patients, marked pigmentation is frequently observed in BCC lesions. Although many authors have documented the incidence of pigmentation in BCCs, its pathogenesis, especially mechanisms associated with sun exposure, have rarely been studied. OBJECTIVE: This study aimed to evaluate the expression pattern of melanin pigments and melanocytes in BCCs of sun-exposed and non-exposed areas of skin and investigate the association of ultraviolet radiation with the pigmentation process of BCCs. METHODS: We examined 30 cases of BCCs occurring in sun-exposed areas of skin, and 8 cases of non-exposed areas of skin, using the Fontana-Masson and MART-1 immunohistochemical methods, with paraffin-embedded sections. RESULTS: Most melanin was found in tumor nests and surrounding dermal stroma (53.0%) and was superficially (60.0%) or fairly uniformly (33.3%) distributed in BCCs of sun-exposed areas. In all BCCs of sun-exposed areas, melanocytes were found in tumor nodules, not in dermal stroma. When the staining level of BCCs occurring in sun-exposed areas was compared with that of non-exposed areas, BCCs of sun-exposed areas showed significantly increased expression in Fontana-Masson (p<0.001, chi-square test) and MART-1 (7.75+/-4.77 vs 2.08+/-2.68; p=0.001, Mann-Whitney U-test) stains. CONCLUSION: Our immunohistochemical staining of BCC specimens revealed that ultraviolet radiation is closely associated with the pigmentation process of BCCs. Although accurate mechanisms are not yet established, these findings suggest a basis for the idea that complex phenomenon lead to hyperpigmentation in BCC.

A Case of Eruptive Vellus Hair Cysts That Developed on the Labium Major

Eruptive vellus hair cysts are asymptomatic, flesh-colored- to-bluish, 1-to-4 mm-sized papules that are usually located on the chest and extremities of children and young adults. Histologically, small cysts are observed in the mid-dermis and these cysts contain multiple hair shafts and keratinous materials. We report here on a case of eruptive vellus hair cysts that developed on a rare site, the labium major.

A Case of Transient Acrodermatitis Enteropathica with a Normal Serum Zinc Level Localized on the Anogenital Area / 대한피부과학회지

A male full-term infant who had been breast-fed since birth developed an erythematous eroded eruption involving the anogenital area at 1 month of age, and this lesion did not respond to treatment with topical corticosteroids and antimicrobials. He was first seen at our office at 9 months of age. At that time, he had continuous diarrhea, but he had no alopecia, nail dystrophy or acral skin lesions. His serum zinc level was normal and his mother's breast milk zinc level was also normal, but it was not enough for his zinc metabolism. His clinical symptoms and skin lesions were dramatically improved with administering zinc.

A Case of Congenital Cutaneous Candidiasis in a Premature Baby / 대한피부과학회지

Although candidal infections are common in the neonatal period, less than 100 cases of Congenital Cutaneous Candidiais (CCC) have been reported in the English literature. CCC appears to be acquired in the uterus by the ascension of organisms from an infected vagina into the uterine cavity. In this report, we describe a premature baby with CCC. At 6 months, his mother had a vaginal candidial infection which was treated. Her pregnancy terminated in preterm labor at 32 weeks. Desquamated patches that involved the trunk and extremities were noted at birth. The possibility of CCC was considered and numerous psedohyphae and spores were seen in the lesions by KOH microscopic examination. The skin lesions cleared completely after 2 weeks of topical clotrimazole cream.

A Case of Kerion Celsi Caused by Trichophyton mentagrophytes / 대한의진균학회지

Kerion celsi is an inflammatory type of tinea capitis. It is a deep, boggy swelling and is painful. Patchy hair loss and broken hairs, inflammation and scaling are characteristic. We report a case of kerion celsi caused by Trichophyton(T.) mentagrophytes in 4 year-old boy. He presented with 6 cm x 7 cm and 2cm x 2cm sized erythematous boggy masses with multiple pustules and crusts on the vertex. Cultures from a scalp lesion of the patient on Sabouraud dextrose agar media showed T. mentagrophytes. Treatment was done systemically with itraconazole and prednisolone for 14 weeks.