A Case of Primary Cutaneous CD30(Ki-1)-positive Large Cell Lymphoma Showing Repetitive Spontaneous Regression and Recurrences

Primary cutaneous CD30+ large cell lymphoma(LCL) is a rare cutaneous peripheral T cell lymphoma with a favorable prognosis. This lymphoma characteristically presents itself as a solitary or localized skin tumor with frequent cutaneous relapses and partial or complete spontaneous remission. Recently we saw a sixty-three year old male who had developed primary cutaneous CD30+ large cell lymphoma that waxed and waned. He presented with localized multiple nodules that had shown repetitive spontaneous regression and recurrences with the same morphology in the same area for several years. There was no evidence of nodal and visceral involvement. The immunohistochemical studies demonstrated that most neoplastic cells in the tumor were positive for CD30 and pan-T cells and negative for pan-B cells, S-100 proteins, EMA and monocyte-macrophage related antigen(CD68).

bcl-2 and MIB-1 Expression in Basal Cell Carcinoma / 대한피부과학회지

BACKGROUND: bcl-2 is a newly characterized proto-oncogen that has been shown to suppress programmed cell death(apoptosis), which is involved in tumorigenesis, and its expression has been demonstrated within tumor cells in a variety of neoplasms. OBJECTIVE: We examined whether there are differences in bcl-2 expression in basal cell carcinoma and several epidermal keratinocytic tumors. In addition, we evaluated bcl-2 expression according to histological types of basal cell carcinoma as well as the interaction of expression of bcl-2 and MIB-1 protein in BCC subtypes. METHODS: Routine paraffin sections of formalin-fixed sixty tissues(20 BCC, 10 Bowen disease, 10 keratoacanthoma, and 20 SCC) were labelled with anti-bcl-2 monoclonal antibody and MIB-1 using a labelled streptavidin-biotin complex. RESULTS: 1. Twenty cases of basal cell carcinoma were examined and all expressed cytoplasmic bcl-2. Three out of 20 cases of squamous cell carcinoma were focally positive. None of the 10 Bowen disease cases and the 10 keratoacanthoma cases expressed bcl-2. 2. In BCC, bcl-2 immunoreactivity was great in the superficical subtypes which had an indolent growth variant, moderate in the circumscribed types, and weak in the infiltrative types which had aggressive growth variants. 3. Evaluation of the distribution of bcl-2 immunoreactive categories and MIB-1 grades revealed a negative correlation tendency, but no statistical significance. CONCLUSION: Our results suggest the presence of a protection mechanism from apoptosis mediated by bcl-2 protein involved in the neoplastic growth mechanism of BCC. In addition, the observed findings in the expression pattern of bcl-2 and MIB-1 in the BCC subtypes may be due to interaction between bcl-2 and other apoptotic-related oncogens.

A Case of Pseudomycetoma due to Trichophyton Mentagrophytes / 대한피부과학회지

Dermatophytes have been demonstrated infrequently in viable tissues such as dermis, subcutis, lymph nodes, bones and other organs. Mycetoma-like lesions caused by dermatophytes, known as pseudomycetoma, have been very rarely reported. A 56-year-old woman presented with several protruding bean to chestnut-sized subcutaneous nodules on the occipital region of the scalp. She had a long term history of epidermolysis bullosa acquisita and intermittent administration of systemic corticosteroids for 5 years. Histopathology of the subcutaneous nodules showed a well encapsulated granuloma containing characteristic lobulated granules consisted of mycelial aggregates. Trichophyton mentagrophytes grew out on the cultures of Sabouraud's media with excised tissues. Surgical excision and itraconazole 200mg per day for 10 weeks was tried and skin lesions are improved with focal recurrence.