RESUMO
Abstract In Portugal, tetrahydrobiopterin (BH4)-responsive patients with phenylketonuria (PKU) are identified using a loading test (LT). Phenylalanine/natural protein (Phe/NP) intake is increased to elevate blood Phe prior to the LT. In a longitudinal retrospective study, the impact of Phe/NP titration post-LT in 58 patients (19.6 + 8.2 years) with PKU during 4 study periods (SPs) was examined. In SP1 (2010-2013), patients were diet treated only; in SP2 (2014), the Phe/NP titration was followed by the LT in SP3 (2015). In SP4 (2016), patients received diet treatment only (n » 49) or BH4 þdiet (n » 9). The median percentage blood Phe within the target range was higher in SP1 versus SP4 (64 [28-85] vs 45 [0-66]; P < .001). Our results suggest that transient Phe/NP titration, associated with a deliberate increase in NP, may adversely affect metabolic control. Controlled studies are necessary to examine the longer term impact of temporary increased NP with BH4 LT in non-BH4-responsive patients.
RESUMO
OBJECTIVE: To evaluate the prevalence of undernutrition in older adults aged >75 years living in communities and to identify the main factors independently associated with undernutrition. METHODS: A cross-sectional study was conducted using a random sample of family physicians' medical records of 86 older adults aged >75 years living in the community studied. Their nutritional status was evaluated using the Mini Nutritional Assessment. RESULTS: A total of 10.5% of the elderly were undernourished and 41.9% were at undernutrition risk. According to the logistic regression multivariable model, the following characteristics: being widowed (OR=6.7; 95%CI=1.8-24.6); being institutionalized (OR=12.6; 95%CI=1.7-90.5); or having a negative self-perception of health (OR=15.0; 95%CI=3.3-69.1) were independently associated with a significant increase of undernutrition risk. CONCLUSION: The current study shows that undernutrition is highly prevalent in Portuguese older adults aged >75 years living in communities. The major factors independently associated with their undernutrition are being widowed and institutionalized and having negative self-perception of health. The results obtained show that undernutrition and its associated factors are very serious problems for older adults and a challenge in their health care. .
OBJETIVO: Determinar a prevalência de desnutrição em idosos com 75 ou mais anos de idade que vivem em comunidades e identificar os possíveis fatores independentes associados à desnutrição. MÉTODOS: Foi realizado um estudo transversal numa amostra aleatória dos registos de médicos de família de idosos com idades >75 anos. O estado nutricional foi avaliado por meio da Miniavaliação Nutricional. RESULTADOS: Estavam desnutridos 10,5% dos idosos e 41,9% apresentavam risco de desnutrição. De acordo com o modelo de regressão logística multivariável, ser viúvo (OR=6,7; IC95%=1,8-24,6), estar institucionalizado (OR=12,6; IC95%=1,7-90,5) ou ter uma autoperceção de saúde negativa (OR=15,0; IC95%=3,3-69,1) demonstraram estar associados a um aumento significativo do risco de desnutrição. CONCLUSÃO: Segundo o presente estudo, a desnutrição tem uma prevalência elevada em idosos portugueses com idades >75 anos que vivem em comunidades. Os principais fatores associados com a desnutrição são a viuvez, a institucionalização e a autopercepção de saúde negativa. Esses resultados demonstram que a desnutrição e os fatores a ela associados representam um grave problema para os idosos e um desafio para os cuidados de saúde. .