Cardiorespiratory fitness in individuals with type 2 diabetes mellitus: a systematic review and meta-analysis

ABSTRACT Objective: To conduct a systematic review and meta-analysis assessing the cardiorespiratory fitness (CRF) among individuals with and without type 2 diabetes Materials and methods: The current review was registered in PROSPERO under the number CRD42018082718. MEDLINE, EMBASE, and Cochrane Library databases were searched from inception through February 2022. Eligibility criteria consisted of observational or interventional studies that evaluated CRF through cardiopulmonary exercise testing or six-minute walk test in individuals with type 2 diabetes compared with individuals without type 2 diabetes. For data extraction, we used baseline CRF assessments of randomized clinical trials or follow-up CRF assessments in observational studies. We performed a meta-analysis using maximal oxygen consumption (VO2max), and distance walked in the 6MWT as primary outcomes. They were extracted and expressed as mean differences (MDs) and 95% CIs between treatment and comparator groups. The meta-analysis was conducted using Review Manager (RevMan) software. Results: Out of 8,347 studies retrieved, 77 were included. Compared with individuals without type 2 diabetes, individuals with diabetes achieved a lower VO2max (−5.84 mL.kg−1.min−1, 95% CI −6.93, −4.76 mL.kg−1.min−1, p = <0.0001; I2 = 91%, p for heterogeneity < 0.0001), and a smaller distance walked in 6MWT (−93.30 meters, 95% CI −141.2, −45.4 meters, p > 0.0001; I2: 94%, p for heterogeneity < 0.0001). Conclusion: Type 2 diabetes was associated with lower cardiorespiratory fitness, as observed by lower VO2max on maximal tests, and smaller distance walked in 6MWT, however the quality of studies was low.

Is Frailty Syndrome a Predictor of Morbimortality in Postoperative Cardiac Surgery? - A Retrospective Cohort Study

Abstract Background Frailty is a biological syndrome suggested as a better predictor of morbimortality than chronological age. Objective To assess associations between frailty and morbimortality outcomes in postoperative cardiac surgery. Methods A retrospective cohort study was conducted with cardiac surgery patients. Frailty and maximal inspiratory pressure (MIP) were assessed before surgery. Postoperative outcomes were: extracorporeal circulation time; use of vasopressor; mean arterial pressure (MAP); red blood cell (RBC) transfusion; cardiac arrhythmia and/or heart arrest; presence of intra-aortic balloon pump; antibiotic use; extubation time; length of stay in the intensive care unit (ICU); length of postoperative stay; mortality. One-way ANOVA was used to compare postoperative variables between frailty categories; Spearman was used to evaluate the correlations between frailty and postoperative variables. Age, sex, and MIP were introduced into multiple regression models to find the independent association between postoperative variables and frailty. A significance level of p < 0.05 was adopted. Results The medical records of 200 patients were analyzed (65.7±7.2 years; 68.5% men; 63.5% non-frail, 22.5% pre-frail, 14% frail). Frailty was not a predictor of postoperative outcomes. Age was an independent predictor for alterations in MAP (PR: 1.028, 95% CI: 1.003-1.053, p=0.025), need for RBC transfusion (PR: 1.034, 95% CI: 1.007-1.062, p=0.014), longer extubation time (PR: 1.052, 95% CI: 1.023-1.083, p<0.001), length of stay in the ICU (ß: 0.031, 95% CI: 0.010-0.053, p=0.005), length of postoperative stay (ß: 0.017, 95% CI: 0.003-0.031, p=0.015). Conclusions Frailty was not a predictor of morbimortality following cardiac surgery in middle-aged and older adults; however, age did predict morbidities in this setting.

Atividade física para gestantes e mulheres no pós-parto: Guia de Atividade Física para a População Brasileira / Physical activity for pregnant and postpartum women: Physical Activity Guidelines for the Brazilian Population

Este artigo tem por objetivo apresentar as recomendações de atividade física para gestantes e mu-lheres no pós-parto desenvolvidas para o Guia de Atividade Física para a População Brasileira. Para isso, utilizou-se uma abordagem de métodos mistos que incluiu quatro etapas: 1) levantamento das diretrizes internacionais mais recentes; 2) revisão narrativa de literatura sobre efeitos da prática de atividade física durante a gestação para a saúde da mulher e do bebê; 3) escuta com gestantes, mu-lheres no pós-parto, profissionais e pesquisadores; 4) consulta pública. As evidências sumarizadas suportam que a prática de atividade física durante a gestação e no período pós-parto é segura, traz be-nefícios à saúde da mãe e do bebê, e reduz os riscos de algumas complicações relacionadas à gestação. Gestantes devem ser incentivadas a realizar pelo menos 150 minutos por semana de atividade física de intensidade moderada. Gestantes com contraindicações devem procurar auxílio de profissionais qualificados. Em alguns casos, a prática de atividade física durante a gestação não é recomendada. Este documento servirá como ferramenta para nortear profissionais de saúde que atuam com ges-tantes e mulheres no pós-parto e irá orientar a população-alvo quanto a prática de atividade física

This manuscript aims to present the recommendations of physical activity for pregnant and postpartum women developed for the Physical Activity Guidelines for the Brazilian Population. A mixed-method ap-proach that included four steps was used: 1) review of the most recent international guidelines for physical activity during pregnancy; 2) narrative literature review on the effects of physical activity during pregnancy on the health of the woman and the baby; 3) consultation with pregnant women, postpartum women, pro-fessionals and researchers; 4) public consultation. The summarized evidence supports that physical activity during pregnancy and in the postpartum is safe, has benefits to the health of the mother and baby, and reduces the risks of some complications related to pregnancy. Pregnancy should be encouraged to do at least 150 min-utes a week of moderate intensity physical activity. Pregnancy women with contraindications should seek help from qualified professionals. In some cases, physical activity during pregnancy is not recommended. This document will be used as a tool to guide health professionals who work with pregnant women and women in the postpartum period. Also, it will inform and guide women during pregnancy and postpartum about the benefits of physical activity

Déficit bilateral: origem, mecanismos e implicações para o treino de força / Bilateral deficit: origins, mechanisms, and implications for strength training

Vários estudos têm demonstrado uma menor capacidade de gerar força quando os exercícios de um programa de treinamento são executados bilateralmente em relação à soma da força executada pelos membros separadamente. Esse fenômeno, que tem sido bem descrito na literatura científica, é chamado de déficit bilateral. Os mecanismos causadores do déficit não são totalmente claros, mas parecem estar relacionados a mecanismos neurais, como um bloqueio dos hemisférios cerebrais ocorrido durante a contração bilateral que reduz a ativação de unidades motoras e a força produzida. Em relação a cada forma de execução (unilateral e bilateral) a longo prazo, as adaptações parecem ser específicas ao tipo de contração utilizada durante o treinamento. Portanto, em consideração à relevância da realização de exercícios executados unilateralmente e bilateralmente dentro de um programa de treino de força, assim como o efeito de cada forma de execução a longo prazo nas adaptações morfológicas e neurológicas do treinamento, esse artigo teve como objetivos caracterizar o fenômeno déficit bilateral, explorar seus principais mecanismos causadores, bem como discutir a influência de cada tipo de treinamento (unilateral e bilateral) nas adaptações do treinamento de força.

Several studies have demonstrated a lower capacity to generate force when the exercises of the training program are performed bilaterally than when compared to the sum of the strength produced by each limb separately. This phenomenon, one that has been well documented in the scientific literature, is called "bilateral deficit." The underlying mechanisms of the bilateral deficit are not fully clear, but they seem to be related to neural mechanisms, such as a blockage of the brain hemispheres, that may occur during bilateral contractions thus reducing the activation of motor units and therefore the strength produced. In relation to each execution form (unilateral and bilateral) in the long term, the adaptations appear to be specific to the type of contraction performed in the training. Therefore, due to the relevance of the exercises performed unilaterally and bilaterally in the strength training program, as well as the long-term effect of each execution form in the morphological and neurological adaptations to training, the aim of this article is to characterize the bilateral deficit phenomenon, to explore its main causative mechanisms, and to discuss the influence of each training type (unilateral and bilateral) in the adaptations of strength training.

Avaliação do déficit bilateral em contrações isométricas dos extensores de joelhos / Evaluation of bilateral deficit in isometric contractions of the knee extensors

O treinamento de força tem sido referido como uma importante ferramenta para o incremento e a manutenção da saúde. Os exercícios que compõem um programa de treino podem ser executados em condição unilateral ou bilateral. Alguns estudos têm apresentado valores mais reduzidos de produção de força e sinal eletromiográfico em condições bilaterais do que o somatório desses valores em condições unilaterais. Essa diferença na produção de força, bem como no sinal eletromiográfico é denominada déficit bilateral. O objetivo do presente estudo foi avaliar a produção de força e a atividade eletromiográfica dos músculos reto da coxa e vasto lateral no exercício de extensão isométrica de joelhos, nas condições unilateral e bilateral. A amostra foi constituída de 10 indivíduos do sexo masculino, com idades entre 18 e 30 anos, não praticantes de treinamento de força. Foram registrados os valores de força e atividade elétrica com a utilização de uma célula de carga e eletrodos de superfície, respectivamente, no teste isométrico de extensão de joelhos (120º). Os resultados apontaram valores maiores (p<0,05) para a produção de força e sinal eletromiográfico na condição unilateral do exercício, reportando um déficit bilateral tanto na força como na atividade eletromiográfica. Estes resultados sugerem que o treino unilateral promove maior estímulo muscular, constituindo-se como uma importante estratégia a ser utilizada na prescrição dos exercícios de força.

Strength training has been reported as an important tool for enhancing and maintaining health. Resistance exercises can be executed unilaterally or bilaterally. Some studies have reported lower strength and electromyography (EMG) signal values in bilateral conditions than the sum of these values in unilateral conditions. This difference in strength and EMG is called the bilateral deficit. The aim of this study was to evaluate the strength and EMG activity of the rectus femoris and vastus lateralis during unilateral and bilateral isometric knee extension. The sample consisted of 10 non-resistance trained males aged 18 to 30 years. Strength and EMG were recorded through use of a load cell and surface electrodes, respectively. A 120º knee extension was used for the isometric knee extension test. The results showed significantly higher values for strength and EMG signal (p <0.05) in unilateral conditions, as well as bilateral deficit in both strength and EMG signal. These results suggest that unilateral training promotes greater muscle stimulation, and can thus represent an important strategy to be used in the prescription of strength training exercises.