Study on Blood Biochemical Indexes of NAFLD in Rabbits / 医学研究杂志

Objective To determine the relationship between blood biochemical indexes and severity of NAFLD by establishing various models of NAFLD with different degrees in rabbits. Methods Thirty-two healthy rabbits were randomly divided into normal control (n=8) and three experimental groups(n=24). Fatty liver animal models were established by giving high fat,high sugar diet. The serum TG,TC,AST,ALT and pathological evaluation were detected respectively after 4,6 and 8 weeks. Results The rabbits developed hyperlipidemia and slight fatty liver after four weeks. Along with the worsening of fat liver,the serum TG level kept rising.Conclusion The blood biochemical indexes can serve as a reliable technique for diagnosing fatty liver disease in clinical.