RESUMO
Lauric, Myristic and Palmitic acids had no appreciable effect whereas Stearic, Oleic and Linoleic acids caused some reduction in dog blood pressure. Pressor responses to epinephrine and nor-epinephrine were potentiated whereas the depressor response to isoproterenol was reduced during the infusion of fatty acids in dogs. ACTH alone, which causes mobilization of free fatty acids had no appreciable effect on blood pressure responses to catecholamines, however, its administration followed by salicylate produced marked potentiation of the pressor responses to epinephrine and nor-epinephrine; the depressor response to isoproterenol was reduced.
Assuntos
Hormônio Adrenocorticotrópico/farmacologia , Animais , Pressão Sanguínea/efeitos dos fármacos , Catecolaminas/farmacologia , Cães , Sinergismo Farmacológico , Epinefrina/farmacologia , Ácidos Graxos/farmacologia , Feminino , Isoproterenol/antagonistas & inibidores , Masculino , Norepinefrina/farmacologia , Salicilatos/farmacologiaRESUMO
All the Krebs metabolites except pyruvate, lactate, acetate and succinate reduced the force and rate of myocardial contractions and also decreased cardiac output in frog. Succinate on the contrary was found to augment the rate and force of heart. The cardiac stimulation produced by epinephrine was reduced by fumarate, malate, oxaloacetate and alpha-oxoglutarate, whereas transaconitate and citrate produced only a slight inhibition. Pyruvate, lactate, acetate and succinate did not alter cardiac response to epinephrine.