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Biocell ; 21(1): 39-46, Apr. 1997.
Artigo em Inglês | LILACS | ID: lil-335977

RESUMO

In order to clearly visualize blood vessels, the monoclonal antibody (mAb) MEC 13.3 was used for an immunohistochemical staining on frozen sections of different mice mammary tumors. MEC 13.3 mAb is specific for endothelial cells (ECs) of mouse blood vessels and recognizes a molecule related to the murine form of CD31/PECAM. This mAb with immunoenzymatic technique or immunofluorescent labelling, was found to be a useful tool to quantify tumor neovascularization. Specifically, membrane reinforcement could be observed in vessel ECs, indicating the expression of CD31/ PECAM in their surface. The staining of ECs from tumors and from normal tissues was also compared. In this work, the use of MEC13.3 mAb is reported to recognize mice mammary tumor ECs as a useful tool to identify neovascularization. It would also be helpful for research on the origin and function of vascular endothelium in murine tumor experimental models.


Assuntos
Animais , Feminino , Camundongos , Adenocarcinoma , Anticorpos Monoclonais , Endotélio Vascular , Neoplasias Mamárias Experimentais , Especificidade de Anticorpos , Reações Antígeno-Anticorpo , Endotélio Vascular , Imuno-Histoquímica , Glândulas Mamárias Animais , Camundongos Endogâmicos BALB C , Microcirculação , Células Tumorais Cultivadas
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