Analysis of MMP-3 polymorphism in osseointegrated implant failure

Polymorphisms in matrix metalloproteinases (MMPs) genes have been associated with several pathologies, including dental implant loss. MMP-3 is crucial to the connective tissue remodeling process. The objective of this study was to investigate the possible relationship between -1612 MMP-3 polymorphism and the early implant failure. A sample of 240 non-smokers was divided: test group 120 patients with one or more early failed implants and control group 120 patients with one or more healthy implants. Genomic DNA from oral mucosa was analyzed by PCR-RFLP. No association of early implant loss with genotypes and alleles of the -1612 polymorphism in MMP-3 were found by the Chi-squared test. Only the presence of the -1612 polymorphism of MMP-3 is not a genetic risk factor for early loss of implants (AU)

Profilaxia da endocardite bacteriana na clínica odontológica - o que mudou nos últimos anos? / Bacterial endocarditis prophylaxis in Dentistry. What is new?

Procedimentos odontológicos que causam bacteremia transitória, ou seja, a invasão de bactérias da microbiota bucal para a circulação sangüínea, ainda são comumente associados à etiopatogenia da endocardite bacteriana. No entanto, estudos recentes mostram que esta associação talvez seja equivocada. Da mesma forma, ainda pairam dúvidas quanto à eficácia dos antibióticos na prevenção desta doença e aos mecanismos pelos quais exerceriam a ação profilática; também é questionado se o risco de efeitos adversos por parte destes fármacos não seria maior que o benefício previsto. Com base numa revisão da literatura, são apresentados argumentos para tentar responder estas e outras perguntas a respeito da profilaxia da endocardite bacteriana na clínica odontológica.

Analgesic choice in dentistry. Part II: the toxicity

Nonopioid analgesics are widely prescribed in dentistry. The first article of this series reviewed the mechanism of action of acetylsalicylic acid (aspirin), acetaminophen (paracetamol) and dipyrone; this part discusses the risks related to the use of these drugs. Paracetamol and dipyrone in therapeutic doses, unlike aspirin, do not cause nausea, do not interfere with protrombin time, do not inhibit the platelet aggregation, and do not produce as many side effects as does aspirin. The adverse reactions in relation to paracetamol seem to be restricted to situations where acute overdosage occurs. In relation to dipyrone, blood dyscrasias such as the agranulocytosis are the main adverse reactions.

Analgesic choice in dentistry. Part I: the mechanism of action / Escolha analgésica na odontologia. Parte I: o mecanismo de ação

Analgesics are frequently used in dentistry for the management of dental pain. Dental clinicians should choose the medicine based on its mechanism of action and toxicity, to promote a successful analgesic effect as well as comfort to the patient. The purpose of this firstarticle is to describe the pharmacological mechanisms of action of the three analgesics considered for the management of mild to moderate acute dental pain

Verificação da variação da pressão arterial pelo uso de anestésicos locais com vasoconstritor / Verification of arterial blood pressure wich local anesthetics associated or not to vasoconstrictors

Os autores realizaram estudos com 100 pacientes divididos em 4 grupos, os quais foram anestesiados com lidocaína, variando apenas no uso ou não de vasoconstritor e no tipo de vasoconstritor associado (adrenalina ou noradrenalina 1:50.000). Os pacientes foram submetidos a exodontia, com aferição da pressão arterial antes do início do procedimento anestésico e após exodontia. Nos pacientes que receberam anestésico com vasoconstritor, normotensos ou hipertensos, não houve aumento significativo da pressão arterial; no grupo onde o sal anestésico não continha vasoconstritor, houve aumento estatisticamente significativo da pressão arterial