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1.
Braz. j. med. biol. res ; 34(3): 413-415, Mar. 2001. tab
Artigo em Inglês | LILACS | ID: lil-281624

RESUMO

Ascending aorta coarctation was produced by a minimally invasive technique in rabbits. Animal mortality was 5 percent. Morphometric and hemodynamic parameters were evaluated. A parabiotically isolated heart model was used to assess the hemodynamic parameters. Left ventricular weight/body weight ratio and muscle area showed clear evidence of hypertrophy when compared to control. The hemodynamic changes in the isolated heart model suggested decreased diastolic and systolic function in the coarcted group. The present model produced hypertrophy with low mortality rates as a result of its less invasive nature


Assuntos
Animais , Aorta/cirurgia , Coartação Aórtica/cirurgia , Hipertrofia Ventricular Esquerda/fisiopatologia , Procedimentos Cirúrgicos Minimamente Invasivos/métodos , Peso Corporal , Hemodinâmica , Modelos Animais , Coelhos
2.
Braz. j. med. biol. res ; 26(6): 605-8, Jun. 1993. ilus, tab
Artigo em Inglês | LILACS | ID: lil-148712

RESUMO

The changes of arterial pressure promoted by bolus injection of 50 micrograms phenylephrine (PHE) were studied in 20 atropinized patients (5 normal subjects, 13 patients with mitral valve disease, 1 patient with essential arterial hypertension and 1 patient with hypertrophic cardiomyopathy) submitted to routine catheterism. Patients with aortic valve disease, left ventricular outflow tract obstruction and intracardiac shunt were excluded from the study. All patients were in sinus rhythm, without heart failure. Arterial pressure started to increase at 14.8 +/- 5.4 s (range, 5.6 to 27 s; mean +/- SD) after PHE. There was an increase of 37.8 +/- 16.7 mmHg (range, 12.5 to 70 mmHg) in systolic pressure and of 26.6 +/- 11.1 mmHg (range, 7.5 to 42.5 mmHg) in diastolic pressure. Peak hypertension was attained at 36.6 +/- 16.4 s (range, 10.8 to 64.9 s) and hypertension continued for 176 +/- 92 s (range, 11 to 365 s). Heart rate was 114 +/- 21 bpm before PHE and 111 +/- 21 bpm (P < 0.05) after PHE. There were no adverse events associated with intravenous PHE injection in any patient, in accordance with the general view that bolus injection of PHE is a safe and practical maneuver to promote arterial hypertension


Assuntos
Humanos , Masculino , Feminino , Hipertensão/fisiopatologia , Fenilefrina/administração & dosagem , Pressão Arterial , Atropina/administração & dosagem , Frequência Cardíaca , Injeções Intravenosas , Fenilefrina/farmacologia , Fatores de Tempo
3.
Braz. j. med. biol. res ; 26(2): 173-6, Feb. 1993. graf
Artigo em Inglês | LILACS | ID: lil-148683

RESUMO

The effect of changes in left ventricular (LV) shape and dimensions due to acute arterial hypertension induced by mechanical obstruction of the aorta for 10 min on LV mass values estimated by M-mode echocardiogram was studied in 14 anesthetized dogs. Although the systolic pressure increased from 117.5 +/- 19.9 to 175.4 +/- 22.9 mmHg altered ventricular diameter from 2.77 +/- 0.49 cm to 3.17 +/- 0.67 cm (P < 0.05) and wall thickness from 0.83 +/- 0.09 to 0.75 +/- 0.09 cm (P < 0.05), LV mass estimated before (73.5 +/- 19.1 g) and after (78.3 +/- 26.4 g) hypertension was not significantly different. We demonstrate here for the first time that changes in LV dimensions induced by acute arterial hypertension do not modify LV mass values estimated by the M-mode electrocardiogram method


Assuntos
Animais , Cães , Hipertensão , Hipertrofia Ventricular Esquerda , Doença Aguda , Ecocardiografia , Ventrículos do Coração
4.
Braz. j. med. biol. res ; 24(4): 383-94, 1991. tab
Artigo em Inglês | LILACS | ID: lil-99467

RESUMO

A method for obtaining the end-systolic left ventricular (LV) pressure-diameter and stress-diameter relationship in man was critically analyzed. Pressure-diameter and stress-diameter relationship were determined throughout the cardiac cycle by combining standard LV manometry with M-mode echocardiography. Nine adult patients with heart disease and without heart failure were studied during intracardiac catheterization under three different conditions of arterial pressure, i.e., basal (B) conditions (mean ñ SD systolic pressure, 102 ñ 10 mmHg) and two stable states of arterial hypertension (HI, 121 ñ 12 mmHg; HII, 147 ñ 17 mmHg) induced by venous infusion of phenylephrine after parasympathetic autonomic blockade with 0.04 mg/Kg atrophine. Significant reflex heart rate variation with arterial hypertension was observed (B, 115 ñ 20bpm; HI, 103 ñ 14 bpm; HII, 101 ñ 13 bpm) in spite of the parasympathetic blockade with atrophine. The linear end-systolic pressure-diameter and stress-diameter relationships ranged from 53.0 to 160.0 mmHg/cm and from 97.0 to 195.0 g/cm3, respectively. The end-systolic LV pressure-diameter and stress-diameter relationship lines presented high and variable slopes. The slopes, which are indicators of myocardial contractility, are susceptile to modifications by small deviations in the measurement of the ventricular diameter or by delay in the pressure curve recording


Assuntos
Humanos , Adulto , Ecocardiografia/métodos , Manometria/métodos , Volume Sistólico/fisiologia , Atropina/farmacologia , Cardiopatias/fisiopatologia , Frequência Cardíaca/fisiologia , Hipertensão/induzido quimicamente , Hipertensão/fisiopatologia , Contração Miocárdica/efeitos dos fármacos , Contração Miocárdica/fisiologia , Fenilefrina/farmacologia , Sensibilidade e Especificidade , Estimulação Química , Função Ventricular Esquerda/fisiologia
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