A Possible Case of Epidermolysis Bullosa Simplex with Mottled Pigmentation / 대한피부과학회지

Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP) is a rare subtype of EBS and characterized by blistering of the skin, mottled pigmentation, and palmoplantar hyperkeratosis. We report a 3-year-old boy with mottled pigmentation on the posterior neck, flank, buttock, and extremities, blisters on palm, and skin-colored keratotic papules on the hands and feet. He had had a history of blistering on his calves. His mother has similar skin lesions to her son's.

Hypertrichosis in a Woman During Treatment with 3% Topical Minoxidil

Hypertrichosis has been frequently observed during the oral administration of the potent antihypertensive agent, minoxidil. However, hypertrichosis is uncommon after treatment with topical minoxidil for alopecia, and usually occurs in areas close to the site of the application. We describe a 52-year-old woman with diffuse facial hypertrichosis. She developed abnormal hypertrichosis while applying the optimal dose of 3% topical minoxidil for 2 months for the treatment of androgenetic alopecia.

A Case of Dowling-Degos Disease / 대한피부과학회지

Dowling-Degos disease, or reticular pigmented anomaly of the flexures, is a rare genodermatosis characterized by an acquired reticular macular hyperpigmentation that initially affects the axillae and groin and later involves intergluteal and inframammary folds, the neck, trunk, and arms. We report a case of Dowling-Degos disease occurring in a 40-year-old woman who has typical hyperpigmentation on flexural areas without any family history and has vesicles on the lip and oral mucosae.

Periumbilical Perforating Pseudoxanthoma Elasticum

Periumbilical perforating pseudoxanthoma elasticum (PPPXE) is a localized acquired disorder found most frequently in obese, multiparous, middle-aged women. It is characterized clinically by yellowish, lax, well-circumscribed, reticulated or cobblestoned patches or plaques in the periumbilical region. Multiparity, obesity, massive ascites, and abdominal surgery are thought to the initiating factors. There is controversy about the etiology of PPPXE. Some authors have classified it as a separate entity from hereditary pseudoxanthoma elasticum (PXE), while others speculate that this condition merely represents a variable expression of PXE in which systemic associations are likely. We report a case of periumbilical perforating pseudoxanthoma elasticum associated with a clinical PXE lesion on the anterior neck.

A case of Angiolymphoid Hyperplasia with Eosinophilla Associated with Arterlovenous Malformations / 대한피부과학회지

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a benign, uncommon disorder of unknown etiology, that usunlly appears as papules or nodules on the head and neck. Histopathologically, ALHE is a angioproliferating lesion which shows characteristically plump epithelioid or histiocytoid endothelial cells, accompanied by an inflammatory infiltrate that mainly consists of lymphocytes and eosinophils. We report a case of angiolymphoid hyperplasia with eosinophila associated with arteriovenous malformations in a 23-year-old man. In our patient, we observed arteriovenous malformation, changes which could have occurred by vascular repair due to a vascular malformation.

A Case of Multiple Bowen's Disease with Small-Cell Lung Cancer / 대한피부과학회지

Bowen's disease represents an intraepidermal squamous cell carcinoma and can be associated with internal malignancy. Internal cancers originate predominantly from respiratory, gastrointestinal, and genitourinary tracts. A 71-year-old man presented with erythematous crusted plaques with emsion on the right lower abdomen, left elbow, and left 4th finger. He had been diagnosed with small-cell lung cancer 17 months ago. The histopathologic features of the skin lesions showed Bowens disease. The abdominal lesion was removed by surgical excision and the lesions on the elbow and finger were treated by topical 5-FU application.

Two Cases of Cutaneous Metastasis from Small Cell Lung Cancer / 대한피부과학회지

The frequency of metastasis to the skin from lung cancer is 1-12%. The incidence of cutaneous metastasis was high in patients with large-cell lung cancer, whereas squamous cell and small-cell lung cancer showed the least tendency to extend to cutaneous sites. Adenocarcinoma was intermediate in the tendency to metastasize in the skin. Histological findings of small-cell lung cancer show solid, tumor cell nests composed of neoplastic cells with large, round nuclei. So, it is often difficult to distinguish small-cell lung cancer from other poorly differentiated small-cell tumors, such as Merkel cell carcinoma, metastatic carcinoid, lymphoma, etc. We report here two cases of skin metastasis from small-cell lung cancer. Case one was a 74-year-old man presenting with a single, round, dome-shaped nodule on the alar nasi which had been present for 1 month. The second case was a 73-year-old man who had found three, non-tender, freely movable subcutaneous nodules on the abdomen 3 days before. Both cases were diagnosed as small-cell lung cancer. On histopathological examination of the skin lesions, we could observe that small round to oval cells with dark staining nuclei and scant cytoplasms were arranged in anastomosing trabecular streams through the dermis, separated by strands of connective tissue in both cases. In the first case, the tumor cells were positive to cytokeratin and NSE, negative to neurofilament antiagen and LCA.

A Case of Juvenile Xanthogranuloma Associated with Neurofibromatosis / 대한피부과학회지

Neurofibromatosis is a systemic hereditary disorder with varied manifestations in bone, soft tissue, the nervous system, and skin. Neurofibromatosis is characterized by cafe au lait macules, neurofi- bromas, Lisch nodules, optic gliomas, bony dysplasia, intertriginous freckling, and autosomal inheritance. Juvenile xanthogranuloma(JXG) is a benign, self-healing disorder of infants, children, and occa- sionally adults, characterized by yellowish papulonodular lesions located in the skin and other organs and consisting of an infiltrate of histiocytes with a progressively greater degree of lipidation in the absence of metabolic disorders. In 1954 Normland reported the first case of a JXG in a child with numerous cafe au lait macules. Royer, in 1958, reported the triple association of JXG, neurofibromatosis, and leukemia. It is estimated that children with neurofibromatosis and JXG have a higher risk for leukemia than do patients with neurofibromatosis who do not have JXG. In patients with both JXG and neurofibromatosis, long-term follow-up is required because of the additional association with leukemia. We report a case of JXG associated with neurofibromatosis.