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Objective:To explore the neutral mechanism of influence of long-term exposure to high altitude hypoxia environment on the processing stage of conflict inhibition.Methods:Differences in the electroencephalogram during a 2-1 mapping Stroop task were compared between a high-altitude (HA) group ( n=20) who lived in a high-altitude area (3 650 m) for two years, and a low-altitude (LA) group ( n=20) who had never visited high-altitude areas. Results:The HA group had a higher pulse rate ((82.0±9.7)/min vs (74.0±11.3)/min) and lower oxygen saturation level ((90.7±2.8)% vs (97.4±1.1)%) compared with LA group.Behavior data showed that the reaction time (RT) in congruent (CO) condition was shorter than that in stimulus incogruent (SI) condition, and the RT in SI condition was shorter than that in RI condition ((707.91±70.33)ms vs (753.76±72.96)ms vs (803.88±73.21)ms); accuracy(ACC) rate in SI condition was higher than CO condition, and the ACC in CO condition was higher than RI condition((96.35±2.91)% vs (95.90±2.83)% vs (91.55±5.22)%). And the response conflict effect was larger than the stimulus conflict effect((49.76±33.90) vs (23.60±30.20)). The differences were all statistically significant (all P<0.01). In SI condition, the RT of HA group was longer than LA group((730.43±60.50)ms vs (777.09±78.23)ms) ( P<0.05). As for the EEG, the amplitude of P2((6.18±0.62)μV vs (3.21±0.62)μV) and N450((1.39±1.48)μV vs (5.91±1.48)μV) component of the HA group were higher those that of the LA group.The amplitude of N450 at P4 electrode site was larger than that at P3 electrode site in HA group((2.26±1.34)μV vs (0.62±1.43)μV). The differences were all statistically significant (all P<0.05). Conclusion:Long-term exposure to high altitude hypoxia environment affects the early stage of stimulus perception and task retrieval, as well as the conflict monitoring in later stage of stimulus and response conflict.The HA group need compensation of right parietal to complete the conflict monitoring of stimulus and response conflict.
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Objective To explore the impact of emotional conflicts on the emotional attention pro-cessing between the elderly and the young. Methods A total of 37 young and 37 elderly participants were enrolled in the study. 2 (group:old group,young group) × 2 (Emotional valence of face:happy,fear) × 2 ( cue type:consistent and inconsistent) mixed experimental design was used among the emotional stroop task and eye tracking task for all of subjects. Results (1) Behavioral response analysis showed that stroop in-terference effects in young and old groups were not significant under different emotional conditions (F=0. 02, P>0. 05). (2) The internal characteristics of the face for the gaze time were analyzed,and the total gaze time of the elderly group (( 402. 28 ± 15. 88) ms ) was significantly longer than that of the younger group ((340. 52±15. 88) ms) under the happy-inconsistent condition(t=2. 75,P<0. 05). The total gaze time of the elderly group under the happy-inconsistent condition was significantly longer than under the fear-inconsis-tent condition((365. 96±13. 95) ms)(t=4. 32,P<0. 05). The first gaze time for a happy face was signifi-cantly longer than that for the fear face((315. 56±13. 13)ms vs (293. 51±13. 23)ms,t=4. 33,P<0. 05), and also showed a positive effect. Conclusion Emotional conflicts have an impact on the emotional atten-tion processing of the elderly,and the elderly are more likely to process the positive stimulation in the control stage.
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Objective: To test applicability of the Center for Epidemiological Studies Depression Scale (CES-D) in different age groups in urban China, and to develop age norms. Methods: In this cross-sectional study, the CES-D was administrated to 16047 community participants with average age of (37.7±21.3) years (age ranged 11～100) in 21 provinces, who were as the norming sample. Criterion validity was tested in 349 psychiatric patients with average age of (32.0±12.1) years (age ranged 16～81) in 4 cities. A subsample (199 workers, 100 col-lege students, and 30 teachers in Beijing, Dongguan, and Baotou) was drawn from the national sample to provide 8 week interval test-retest reliability. Results: The Cronbach α was 0.90 for the scale, and 0.68～0.86 for its fac-tors. The 8 week interval test-retest correlation was 0.49 for the scale (P <0.01) and 0.39～0.51 for factors (P<0.01) . The result of confirmatory factor analysis supported the original 4-factor structure (RMSEA=0.057, CFI =0.976, GFI=0.948) . Patients scored higher than community sample [(21.72±13.39 ) vs.(13.24±10.33),P <0.01], and depression patients scored the highest [(27.82±14.42), P<0.01] . Age difference was signifi-cant. Age groups over 60-year-old scored higher than all the other age groups under 60-year-old (P<0.01). Con-clusion: The Chinese version of CES-D shows good refiability and validity across all ages in urban population-
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Objective: To explore the depression stares of the elderly experienced the Wenchuan earthquake and to know the related factors. Methods: Using the convenient sampling method, 390 elderly living in Chengdu and Deyang City were included in this investigation. Demographic data was recorded and the Center for Epidemiolog-ic Studies Depression (CES-D) was applied individually. Results: In this sample, 9.8% of the elderly had sus-pected depression symptom and 30.3% had depression symptom. Depression status was related to sex, education,habitual residence, occupation and experiences in earthquake. Compared with the elderly who were males, with middle school education degree, without horrible experiences in the past, with less fearful/helpless/horrible feel-ings in earthquake, the elderly who were females (OR=2.03), with education degree below primary school (OR =2.59), with horrible experiences in the past (OR=2.06), and with strong fearful/helpless/horrible feeling in earthquake (OR=1.59), had more serious depression. Conclusion: After 8 months of Wenchuan earthquake, lo-cal elderly victims are still in severe depression. The elderly who are female, with low education level, engaged in farm work, suffered great loss should be paid special attention.