RESUMO
Our aim was to study the susceptibility of Streptococcus pneumoniae to antibiotics in patients with pneumococcal meningitis and to search for the prognosis factors in those patients. We have studied retrospectively 31 cases of pneumococcal meningitis. Comparisons were performed with univariate analysis. The mean age was 36,7 +/- 20,5 years [ranged: 9 and 78 years]. The sex ratio was 3,4. The susceptibility of Streptococcus pneumoniae to penicillin G was affected in 10 cases [33% of isolated pneumococcus. The MIC to penicillin G was >/= 2 in only one case. The hospital mortality was 26% [8/31]. With univariate analysis, factors associated with death were: age >/= 55 years [Ss p= 0,006, OR: 17.2; IC[95%]: 2.3-134], albuminorachie >/= 7g/l [p= 0,002, OR: 22; IC[95%]: 1,9-251], shock [p= 0,031, OR: 6.7; IC[95%],: 1.05-42] and Glasgow Coma Score [GCS] = 8 [p=0,001, OR: 20; IC[95%]: 2,68-149]. No susceptibility to penicillin G is not associated with a worse outcome in patients with pneumococcal meningitis. An age 55 years, albuminorachie >/= 7g/l shock and Glasgow Coma Score = 8 at admission were determinant of the prognosis in our study
Assuntos
Humanos , Masculino , Feminino , Streptococcus pneumoniae/efeitos dos fármacos , Estudos Retrospectivos , Prognóstico , Resultado do Tratamento , Fatores de RiscoRESUMO
Purpose: To estimate the consumption of antibiotics in our hospital and to determine the points at which the recommendations of good practice of antibiotherapy will be targeted. Patients and methods: Our study is a one day prevalence study where antibiotic prescriptions are analyzed by a group of 6 doctors referents in antibiotherapy. During the study day, 443 patients were studied. Means age was 44.2 +/- 23.3 years [range: 1 and 102 years]. 101 infections were diagnosed in 48 patients [10.8%]. 192 patients [43.3%] received antibiotics. Antibiotherapy was curative in 44% of cases. The most prescribed antibiotics were gentamicin [85.2 DDD/1000 patients], metronidazole [79 DDD/1000 patients], and cefotaxime [73.9 DDD/1000 patients]. According to the evaluation group, 30.7% of the antibiotic prescription was considered unjustified. The antibioprophylaxis represents the category most often unjustified [49%]. The molecules in which prescription was frequently considered unjustified are the ciprofloxacin [67%], the amoxicillin-clavulonate [40%] and the cefotaxime [40%]. Our results suggest that an action of good practice should be targeted at the antibioprophylaxis and should concern especially molecules in which prescription was frequently unjustified
Assuntos
Humanos , Antibacterianos , Hospitais Universitários , Uso de MedicamentosRESUMO
Two forms of sympatric mice are captured in North - Tunisia long - tailed mouse and short - tailed mouse. They are often considered as two semi - species of genus Mus, respectively Mus musculus musculus and Mus musculus spretus. They have the same Karyotype [2n = acrocentrics]. The electrophoretic study of total proteins shows up genetics differences. These two forms of mice may be considered as two different species, as like as mices of Europe: Mus,musculus at long-tailed and Mus spretus at short tailed