Untoward effects of quinacrine hydrochloride as observed in 302,206 malaria cases

Observation study was made on 302,206 Filipino malaria patients who were given therapeutic doses of quinacrine hydrochloride (Atabrine). Of the 302,206 cases, 82.46% had vivax malaria and 17.54% had falciparum malaria. Two hundred twenty cases showed one or more untoward effect of the drug. Distribution of the 340 untoward effects observed in these subjects were presented. These untoward effects were temporary in nature and disappeared from one to eight days after the drug was discontinuedSelected untoward effects of drugs included the following: manic excitement, talkativeness, insomnia, depression, delusions, hallucinations, absent-mindedness and toxic psychoses.(Author)