Myocardial blood flow in dogs during gallbladder manipulations

Myocardial Rb clearances were assayed in 22 opened abdomen healthy mongrel dogs to study the behavior of the coronary vascular bed during gallbladder manipulation. Systemic blood pressure and electrocardiogram were monitored by the Grass Polygraph machine during the course of the experiments. Hemoglobin and hematocrit were determined. In 16 dogs the regional myocardial Rb clearances were analyzed by a method previously described during the height of gallbladder manipulation, while in 6 dogs similar clearances were determined while the gallbladder was undisturbedIn both the control and experimental group, the mean systemic blood pressure was comparable. The mean heart rate in gallbladder manipulated dogs was greater than the control (p 0.05). There was no significant variation in hemoglobin and hematocrit. The individual myocardial zone Rb clearance of the gallbladder stimulated dogs, though showed a tendency to increase, did not vary significantly with the corresponding myocardial zone clearance of the control experiment, (p. 0.05) except in regions 1 and 5. (Summary)

Hemodynamic studies after coronary embolization

The hemodynamic effects of coronary embolization were studied in 22 intact anesthetized dogs. Blood flow was measured utilizing two methods: 1) dye-dilution using indocyanine green (in 16 dogs) and 2) Kolin-type of electromagnetic flowmeter implanted around the root of the aorta (in 6 dogs). In the latter group of studies, coronary embolization was done after the animals had recovered from the surgical procedure (3-7 days)The hemodynamics were observed from the time of myocardial injury up to the termination of the experiment (extending up to 4 hours after coronary embolization). Coronary embolization resulted in an immediate and marked decrease in cardiac output (40-50 below the control), severe hypotension (63), elevation of pulmonary arterial pressure (50) and marked elevation of the total peripheral resistance (145). Partial recovery of the hemodynamics occurred within 5 minutes after the heart injury. Later there was, however, a progressive drop in cardiac output while the total peripheral resistance remained elevated. (Summary)

Tyloxapol in bronchial toilet

Fifteen to thirty ml. of tyloxapol was used to nebulize 20 chronic bronchopulmonary patients for 15 minutes every morning for one month except Sunday. Cross over study with same volume of normal saline solution (NSS) and vodka in distilled water were done respectivelyTyloxapol aerosol showed an increase in FVC by 12%, in Fev 1.0 sec. by 26% and in MBC by 21%. The total pulmonary resistance to airflow decreased by 9% without signficant change in dynamic lung compliance. There was no alteration in the respiratory gas exchange. Sputum volume and weight rose, the density dropped, surface tension and viscosity diminished considerablyThe cross-over study with NSS and vodka demonstrated practically no change except for the modest surface tension and viscosity reduction with vodka. The mechanism of the improvement with tyloxapol was explained. (Summary)

The effects of expectorant on cough mechanism

Subjective and objective wise all the expectorants are significantly effective and came out in this order namely; Expectorant C, Expectorant A; and Expectorant B last. Spirometric studies showed that they are all capable to a significant degree to improve pulmonary function. The alteration in the physical character of the sputum is probably the main factor in the benefits derived by the patientsThe drugs were decoded as follows: Expectorant A - Glyceryl Guaiacolate; Expectorant B - Bromehexine; Expectorant C - Ammonium chloride. (Conclusion)

Coronary shock: an experimental study

The hemodynamic effects of coronary embolization were studied in 30 intact anesthetized dogs. Blood flow was measured utilizing two methods: 1) dye-dilution using indocyanine green (in 16 dogs) and 2) Kolin-type of electromagnetic flowmeter implanted around the root of the aorta (in 14 dogs). In the latter group of studies, coronary embolization was done after the animals had recovered from the surgical procedure (3-7 days)The hemodynamics were observed from the time of myocardial injury up to the termination of the experiment (extending up to 4 hours after coronary embolization). Coronary embolization resulted in an immediate and marked decrease in cardiac output (40-50% below the control the control), severe hypotension (63%), elevation of pulmonary arterial pressure (50%) and marked elevation of the total peripheral resistance (145%). Partial recovery of the hemodynamics occurred within 5 minutes after the heart injury. Later there was, however, a progressive drop in cardiac output while the total peripheral resistance remained elevated. The clinical implications of the results were discussed.(Summary)

The effect of L-methylcysteine HCL on chronic obstructive respiratory diseases

Twenty patients with chronic obstructive bronchopulmonary diseases were put on a clinical trial using oral L-methylcysteine hydrochloride compared to placebo. Fifteen patients improved significantly when given the active drug. Five patients did not improve at all. All patients did not show any response to oral placebo. The patients who were benefited by oral L-methylcysteine demonstrated very convincing reduction in sputum viscosity.(Summary)