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Objective To explore the clinical effects of flurbiprofen axetl injection on the treatment of postoperative pain in patients with laparoscopic appendectomy and on the platelet aggregation function.Methods From April 2013 to October 2015,100 laparoscopic appendectomy patients were randomly divided into observation and control groups,50 cases in each group.Observation group was injected flurbiprofen axetl injection 1 mg/kg,the control group was injected normal saline 5 ml.Analgesic effect,platelet aggregation function,and side effect were observed for two groups.Results Activities and resting visual analogue scale (VAS) score were significantly lower after flurbiprofen axetl injection in observation group (P ＜ 0.01),while activities and resting VAS score were not significantly decreased after normal saline used (P ＞ 0.05).Compared to those in control group,activities and resting VAS score at 30 min,1 h,2 h,4 h,and 6 h after flurbiprofen axetl injection in observation group were significantly lower (P ＜0.01).Platelet aggregation level before and after medication in two groups were no significant change (P ＞ 0.05).Drug side effects in two groups were no difference (P ＞ 0.05).Conclusions Patients with laparoscopic appendectomy do well with flurbiprofen axetl injection,and no obvious side effects.It is worthy of clinical application.
RESUMO
Objective To explore preventive effect of low-dose sufentanil combined with parecoxib sodium for hyperalgesia of remifentanil anesthesia after postoperative.Methods A total of 120 patients undergoing elective abdominal surgery under general anesthesia was randomly divided into three groups that were given intraoperative remifentanil infusion.At the 30 minutes before surgery,group A were given intravenous sufentanil 0.1 μg/kg combined with 40 mg parecoxib sodium,group B were given intravenous sufentanil 0.2 μg/kg combined with 40 mg parecoxib sodium,and group C were given normal saline 5 ml.Postoperative recovery time,extubation time,postoperative 1,2,6,12,and 24 h visual analog scale (Visual Analogue Scale/Score,VAS) score,and after 24 h additional analgesia number of cases and the restless occurrence of three groups were compared.Results Awakening time and extubation time of group B was significantly longer than groups A and C [(10.9 ± 1.3) min vs (8.6 ± 0.6) min,(8.2 ± 0.7) min;(14.0 ± 2.1) min vs (10.7 ± 2.2) min,(10.8 ± 1.2) min,all P ＜ 0.01].Each point VAS scores of groups A and B were significantly lower than group C (P ＜0.01).After 24 h,the number of cases additional analgesic medication,and restlessness occurrence of group C were significantly more than the number of cases of groups A and B (P ＜ 0.01),the number of cases and the restless occurrence after 24 h additional analgesic drugs of group A were more than group B,but there was no significant difference between two groups (P ＞ 0.05).Conclusions Low dose sufentanil together with parecoxib sodium can inhibit after-remifentanil-induced hyperalgesia,and will not appear awakening time and extubation time delays and safe.