Expressão de Raiva e Desempenho: Testando Modelos de Moderação / Anger Expression and Performance: Testing Moderation Models

Resumo Tratou-se de um estudo correlacional com 108 líderes e 176 liderados de quatro empresas públicas ou de economia mista em que se testou o efeito da percepção de raiva e de poder do líder no desempenho do liderado, moderado por dois traços pessoais dos liderados (conscienciosidade e agradabilidade). A base teórica foi o modelo EASI (Emotion as Social Information). Os liderados responderam três instrumentos: a) traços pessoais de agradabilidade e conscienciosidade; b) Medida de Poder Social Global do líder; e c) Escala de Percepção da Expressão Emocional de raiva do líder. Os líderes responderam à Medida de Desempenho de Tarefa de seus liderados. Os resultados indicaram que apenas a conscienciosidade moderou a relação entre a percepção de raiva do líder e o desempenho do liderado.

Abstract It was a correlational study with 108 leaders and 176 subordinates from four public and mixed-economy companies, in which the effect of anger perception and leader's power on subordinate´s performance has been tested, moderated by two subordinates' personal traits (conscientiousness and agreeableness). The theoretical basis was the EASI (Emotion as Social Information) model. The subordinates answered three instruments: a) personal traits of agreeableness and conscientiousness; b) Leader's Global Social Power Measure; and c) Leader's Emotional Expression Perception Scale. Leaders responded to the subordinates Task Performance Measure. The results indicated that only conscientiousness moderated the relationship between the leader anger perception and the subordinate´s performance.

Mechanisms and role of microRNA deregulation in cancer onset and progression

MicroRNAs are key regulators of various fundamental biological processes and, although representing only a small portion of the genome, they regulate a much larger population of target genes. Mature microRNAs (miRNAs) are single-stranded RNA molecules of 20-23 nucleotide (nt) length that control gene expression in many cellular processes. These molecules typically reduce the stability of mRNAs, including those of genes that mediate processes in tumorigenesis, such as inflammation, cell cycle regulation, stress response, differentiation, apoptosis and invasion. MicroRNA targeting is mostly achieved through specific base-pairing interactions between the 5' end ('seed' region) of the miRNA and sites within coding and untranslated regions (UTRs) of mRNAs; target sites in the 3' UTR diminish mRNA stability. Since miRNAs frequently target hundreds of mRNAs, miRNA regulatory pathways are complex. Calin and Croce were the first to demonstrate a connection between microRNAs and increased risk of developing cancer, and meanwhile the role of microRNAs in carcinogenesis has definitively been evidenced. It needs to be considered that the complex mechanism of gene regulation by microRNAs is profoundly influenced by variation in gene sequence (polymorphisms) of the target sites. Thus, individual variability could cause patients to present differential risks regarding several diseases. Aiming to provide a critical overview of miRNA dysregulation in cancer, this article reviews the growing number of studies that have shown the importance of these small molecules and how these microRNAs can affect or be affected by genetic and epigenetic mechanisms.

Síndrome hemolítica-urêmica: relato de caso / Hemolytic uremic syndrome: case report

Introdução: A Síndrome Hemolítica-Urêmica (SHU) é uma doença incomum que consiste em anemia hemolítica microangiopática, trombocitopenia e insuficiência renal aguda, com predileção por crianças até três anos de idade. Metodologia: Estudo analítico realizado desde o internamento da paciente no Hospital da Santa Casa de Misericórdia do Pará até o tratamento ambulatorial, por 6 meses. Relato do caso: Paciente do sexo feminino, 14 anos de idade, melanoderma, residente e procedente de Belém-PA, apresentou quadro clínico de edema de face e membros inferiores, hematúria macroscópica, febre moderada, hipertensão arterial, dor epigástrica, palidez cutâneo-mucosa e azotemia. Há dois anos foi diagnosticada púrpura trombocitopênica idiopática (PTI). Nos exames complementares apresentava: Hb: 4,2g por cento;Ht: 10,9 por cento; leucócitos: 15.300/mm; plaquetas: 42.000/mm3; uréia: 295mg/dl e creatinina: 5,7mg/dl. A biópsia renal diagnosticou SHU. Ficou em programa de hemodiálise por dois meses e, atualmente, está em tratamento conservador, com clearence de creatinina de 78, 75ml/min. Considerações Finais: O caso em questão teve uma forma de apresentação atípica, tanto do ponto de vista epidemiológico como clínico, já que a SHU é mais comum em lactentes e o diagnóstico

Changes in nuclear phenotype frequencies following sequential cold shocks in Triatoma infestans (Hemiptera, Reduviidae)

The nuclear phenotypes of Malpighian tubule cells in fifth instar nymphs of Triatoma infestans, one of the most important vectors of Chagas disease, were studied following sequential shocks at 0ºC, separated by intervals of 8 h and 24 h at 30ºC, under conditions of moderate fasting and full nourishment. The insects pertained to colonies reared in the laboratory and originated from domestic specimens collected in the Brazilian states of Säo Paulo (north) and Minas Gerais (south). Since nuclear phenotypes in this species are affected by single cold shocks, it was expected that these phenotypes could also be changed by sequential shocks. Nuclear phenotypes indicative of mechanisms of cell survival (nuclear fusion and heterochromatin decondensation) and cell death (apoptosis and necrosis) were observed concomitantly in all the conditions tested. Nuclear fusion and heterochromatin decondensation were not found relevant for the presumed acquisition of the cold-hardening response in T. infestans. The decreased frequency of apoptosis and necrosis following sequential cold shocks including under fasting conditions, indicated that tolerance to sequential cold shocks occurred in T. infestans of the mentioned origin

Effect of sequential cold shocks on survival and molting rate in Triatoma infestans Klug

The survival and molting incidence in Triatoma infestans, a vector of Chagas disease, were investigated following sequential shocks at 0ºC in fifth instar nymphs under moderate fasting and full nutritional conditions. The shocks were separated by intervals of 8 h and 24 h at 30ºC. The results indicated that in terms of insect survival, T. infestans is tolerant to a single cold shock at 0ºC even for 12 h, or to sequential cold shocks, regardless of the nutritional state of the specimens. In terms of molting rate, fasting enhanced the tolerance to sequential cold shocks, but did not exceed the tolerance acquired by fully-nourished specimens, except when cold shocks were separated by an 8 h interval at 30ºC. The protective action elicited by fasting was assumed to be additive to that induced by a single mild cold shock or sequential cold shocks. The cold-tolerance response of T. infestans may have favoured its survival in areas of South America with low temperatures, even considering that this species is predominantly associated with human habitats