RESUMO
Background: Obesity during childhood is a risk factor for developing cardiovascular diseases during adulthood. Aim: To measure insulin and glucose levels and parameters of insulin resistance in obese, overweight and normal weight Mexican children. Material and Methods: Comparative study of 21 obese children with a body mass index (BMI) over percentile 95, aged 10 ± 1 years (10 males), 14 children aged 10 ± 2 (7 males) with a BMI between percentiles 85 and 94 and 16 children aged 9 ± 2 years (3 males) with a body mass index between percentiles 10 and 84. Body weight, blood pressure and waist circumference were measured and a blood sample was obtained to measure fasting glucose and insulin levels. Homeostasis model of insulin resistance (HOMA) and quantitative insulin sensitivity check index (QUICKI) were calculated. Results: Among obese, overweight and normal weight children, insulin levels were 14.9 (95% CI 10.90-18.99), 7.20 (CI 5.12-9.28) and 4.73 (CI 95% 1.92-7.53) uU/ml, respectively. The figures for HOMA were 3.16 (95% CI 2.20-4.12), 1.49 (95% CI 1.03-1.94) and 0.97 (95% CI 0.35-1.60), respectively. The figures for QUICKI were 0.331 (95% CI 0.319-0.343), 0.371 (95% CI 0.349-0.393) and 0.419 (95% CI 0.391-0.446), respectively. Compared to their normal weight counterparts, the risk of obese children and those with a waist circumference over percentile 90 of having a HOMA over 3.16 was 17 and 10 times higher, respectively. BMI correlated better than waist circumference with insulin levels. Conclusions: Obese children have higher levels of insulin resistance than their normal weight counterparts.
Assuntos
Humanos , Masculino , Feminino , Criança , Resistência à Insulina , Hiperinsulinismo/sangue , Insulina/sangue , Obesidade/sangue , Biomarcadores/sangue , Índice de Massa Corporal , Fatores Sexuais , Fatores de Risco , Circunferência da Cintura , Hiperinsulinismo/diagnóstico , Hiperinsulinismo/etiologia , México/epidemiologia , Obesidade/complicações , Obesidade/epidemiologiaRESUMO
El presente estudio tuvo por objetivo evaluar la calidad lagrimal en el perro sin pelo del Perú mediante el uso de la prueba de tiempo de Ruptura de la película lagrimal precorneal (TRPLP). Material y métodos: El estudio se realizó en la ciudad de Lima entre los meses de Julio a Diciembre del año 2008. Se evaluaron 125 canes de diferentes edades, tamaños y de ambos sexos. Resultados: En los resultados de la prueba de TRPLP se observó un alto porcentaje de perros con mala calidad lagrimal: 94,4% (118/125) en el ojo derecho y el 92% (115/125) en el ojo izquierdo. No se encontró asociación entre el sexo, estrato etáreo y lado del ojo evaluado para la prueba de (TRPLP). Conclusión: Se concluye que existe un porcentaje elevado de perros sin pelo del Perú con una mala Calidad lagrimal...
The purpose of this study was to evaluate the tear quality of Peruvian hairless dog through the use of the tear film break up time (TFBUT). Material and methods: The study took place in Lima Between July 2008 and December 2008. Results: A total of 125 animals of different of poor quality: 94.4% (118/125) in the rigth eye and 92%(115/125) in the left eye and without significant difference due to sex, age and eye side evaluated. Conclusion: It is concluded that a high percentage of peruvian hairless dog a poor tear film quality...