RESUMO
Objective:To evaluate the cost-effectiveness of duloxetine, escitalopram oxalate and mirtazapine in the treatment of depression. Methods:Totally 120 cases of patients were randomly divided into three group. Group A was given duloxetine 40mg twice a day, group B was with escitalopram oxalate at the initial dose of 10mg per day, and up to 20mg per day in 2 weeks, and group C was treated with mirtazapine 30mg per day. The treatment course was eight weeks. At the 1st, 2nd, 3rd, 4th and 8th weekends after the treatment, Hamilton depression scale ( HAMD) was used to evaluate the total effective rate, and treatment emergent symptom scale ( TESS) was applied to assess the adverse drug reactions. Results:The total effective rate of group A, B and C was 87. 5%,90% and 92. 5% with the cost of 23 822. 22 yuan,33 866. 02 yuan and 19 586. 62 yuan, respectively. The cost-effectiveness ratio respectively was 27 225, 37 629 and 21 175. The incidence of adverse reactions respectively was 30%, 30% and 17. 5%. Conclusion:The cost-effectiveness of mirtazapine is the lowest in the treatment of depression, which can be considered as the best treatment regimen.
RESUMO
OBJECTIVE:To probe into the status quo and the tendency of the utilization of psychotropic drugs in our hospital. METHODS:The consumption sum,DDDs and the daily drug cost of psychotropic drugs from 2006 to 2008 were analyzed statistically in this retrospective study. RESULTS & CONCLUSION:The consumption sum of psychotropic drugs in our hospital assumed year-on-year increase tendency. The DDDs of the first generation of psychotropic drugs remained stable. The consumption amount of the non-first generation of antipsychotic drugs increased year on year,with risperidone showing the most rapid increase. Fluoxetine,venlafaxine and paroxetine took the lead among all the antidepressant drugs used. However,the consumption amount of tricyclic antidepressants decreased markedly. Benzodiazepine took the lead among all the antianxiety drugs.