Antlangingenesis of panaxoside-Rg3 on ascitic-fluid type helmtocarcinoma H22 in mice / 中国医师杂志

Objective To observe the antiangiogenesis of panaxoside-Rg3 on mice intraperitoneally implanted with ascites tlnnor cells.Methods 25 female and 25 male Kunming mice were random divided into five groups:Group I injected with normal saline (0.9%NS),Group Ⅱ with cisplatin(DDP 0.5mg/kg),Group Ⅲ,with low-dose panaxoside-Rg3(LPD 0.3mg/kg),Group Ⅳ with middle-dose panaxoside-Rg3(MPD 1.0mg/kg),Group Ⅴ with high-dose panaxoside-Rg3(HPD 3.0mg/kg).Experimental ascitic hepatocarcinoma of H22 lines model were successfully established among all groups,and 24 hours later intraperitoneal infusion of 0.2ml medicines was given to each mouse once every day for 14 days.24 hours after the over of the treatment,all mice were executed.Enzyme linked immunosorbent assay(ELISA)method was used to detectt he different VEGF level in the ascites and serum of all groups and expressions of micmvessel density (MVD)of peritoneum tumor node was calculated by immunohistochemical staining with CD31 antibody.Morphological of tumor cell in abdominal cavity and new vascular in peritoneum tumor node were observed by transmission electron microscope.Results With the increase of concentration of panaxoside-Rg3,expressions of the VEGF level of the ascites and the serum and MVD in peritoneum dropped(P＜0.05)and decreased more than that in the NS group and the DDP group(P＜0.05).Morphological changes of tumor ceHs in panaxoside-Rg3 group were observed with electronic scope,more apoptosis and necrosis cells were found.Capillary vessel basal lamina was smoothing.Condusion Panaxoside-Rg3 decreases the permeability of mierangium and inhibit the neovascula-rization of peritoneum by decreasing the VEGF level,accordingly,panaxoside-Rg3 inhibit the formation of malignant ascites.This would offer foundation of theory for clinical application.

Psychosocial factors and lung cancer development / 中国肺癌杂志

<p><b>BACKGROUND</b>To study the association between psychosocial factors and the development of lung cancer.</p><p><b>METHODS</b>Case-control matched study was employed in the study. A standardized life event, social support and defense mechanisms interview was administered respectively. Total 118 lung cancer patients who were diagnosed pathologically were chosen as case group, and 118 matched healthy people were as control group. The pair had the same gender, the same race, and the same occupation, and lived in the same area, and the age difference between the two groups was ±3 years.</p><p><b>RESULTS</b>Univariate analysis showed that smoking, defect of sleeping, alcohol consuming, smoking and drinking during meal, preserved food consuming, irregularity of life increased the risk of lung cancer development (P < 0.05). The scores of life events, social support had no significant difference between two groups (P > 0.05), but the scores of stress life events was higher in cancer group than that in control group. The immature factors of defense mechanisms in cancer group were higher than those in control group (P < 0.05). Multiple qualified logistic regression showed that smoking and defect of sleeping were the main risk factors of lung cancer genesis.</p><p><b>CONCLUSIONS</b>There is certain association between psychosocial factors and lung cancer development. The immature defensive factor is the psychosocial factor of lung cancer genesis, and smoking, defect of sleeping, alcohol consuming, smoking and drinking during meal, preserved food consuming, irregularity of life are the risk factors of lung cancer.</p>

Navelbine plus cisplatin in the treatment of advanced non-small cell lung cancer / 中国癌症杂志

Purpose:To evaluate the results of combination chemotherapy with navelbine (NVB) and cisplatin (DDP) in patients with stage Ⅲ b—IV non small cell lung cancer (NSCLC), as compared with MVP regimen. Methods:16 cases were treated with MVB+DDP, 20 cases were treated with MVP. Results:The response rate was 50.0% in patients with NVB plus DDP, 40% in those treated with MVP . The major toxic reactions in the two groups were tolerable,being myelo suppression and grstrointestinal reaction. Grade Ⅱ—Ⅳ phlebitis rate was 37.5% in patients with NVB puls DDP, 0.0% in those treated with MVP, respectively ( P 0.05). Conclusions:A higher response rate is attainable with stage Ⅲ b—IV NSCLS treated by navelbine and cisplatin with tolerable toxicity. [

Long Term Results of Inoperable Stage ⅢB, Non-small Cell Lung Cancer / 昆明医科大学学报

The long-term results of 118 cases inoperable stage ⅢB non-small cell lung cancer were reported． All patients received CAP regimen or MVP regimen chemotherapy． 97 patients received radiotherapy, The results showed that 1-, 3-, 5- year survival rates were 53.4%, 19.5% and 8.5% respectively． The 3-, 5- year survival rate for squamous cell carcinoma were higher than those adenocarcinoma (P<0.05)． The 3-, 5- year survival rate for T4N0 M0 were higher than those T3 N3 M0,T4 N1～2 M0 and T4 N3 M0, (P<0.05～0.01)． There was no differencein the 3-, 5-year survival rate between CAP regimen and MVP regimen．

Therapy experience in NHL patients with diabetics / 肿瘤研究与临床

Objective Discuss therapy problems in NHL patients with diabetics. Methods 40 NHL patients with diabetics are treated with chemotherapy containing prednisone. Compare the blood sugar before using prednisone with the one after that, regulate medicines of reducing glucose and at the same time observe the syndromes. Results Limosis blood sugar of patients just in hospital is (6.1?1.3) mmol/L, and after chemotherapy it becomes (6.5?1.2) mmol/L. There is no significant difference between them. Conclusions On the basis of controlling blood sugar effectively, patients with NHL combining diabetics can use prednisone as normal.