prevalence of different classes of lupus nephritis in Jordan university hospital

Systemic lupus erythematosus [SLE] is a systemic autoimmune disease involving almost all organs of the body. There is a high incidence of renal involvement during the course of the disease with varied renal pathologic lesions. A renal biopsy contributes towards diagnosis, prognostic information, and appropriate management. To study the prevalence of different classes of SLE using the International Society of Nephrology/Renal Pathology Society [ISN/RPS] 2003 classification in our facility. This study was carried out at the Jordan University Hospital [JUH] in June and July 2011. We acquired an approval for this study from the IRB [Institutional Review Board] of the Jordan University Hospital. We retrieved 36 renal biopsies from our files beginning from 2002- 2010 that have the diagnosis of SLE and they were reviewed and reclassified by two pathologists. Of the 36 renal biopsies, only one was classified as class I, 5 were class II, one was class III, 23 were class IV, 6 were class V, and none of the biopsies were classified as class VI. Class IV was the most prevalent class in the JUH cases with almost equal numbers of class IVS and IVG subclasses, while there was only a single case of class III [IIIS] which is very low compared to other studies

Salivary gland tumors: a single institutional experience

Tumors of the salivary glands are uncommon. They may be broadly categorized into benign, neoplasms, tumor like conditions and malignant neoplasms. Most salivary gland tumors arise in the parotid gland. The remaining tumors arise in the submandibular, sublingual and minor salivary glands dispersed throughout the aerodigestive submucosa. To study the pattern of salivary gland tumors distribution in Jordan University Hospital [JUH]. This is a retrospective study of cases of salivary gland tumors in JUH, where we collected cases from 2000 - 2011 and classified them into epithelial and non-epithelial tumors, and the epithelial tumors were classified according to the revised WHO 2005 classification of salivary gland tumors. We also studied the age and sex distribution of these cases. Of the 80 salivary gland tumors, 68 were epithelial tumors, 12 were hematolymphoid and benign mesenchymal tumors. Of the epithelial tumors, 57 were benign and 11 were malignant, with a male to female ratio of 3:1. Most tumors originated from the parotid gland, and most of them are benign tumors. Compared to other studies, there were more benign tumors than malignant ones, and more parotid tumors than other salivary gland tumors. There was a striking male predominance in most tumors

Craniopharyngioma in a patient with acromegaly due to a pituitary macroadenoma

We present the first reported case of a craniopharyngioma as a second primary tumor in a patient with acromegaly due to a growth hormone [GH]-secreting pituitary adenoma. The patient was lost for follow-up for 18 years after trans-sphenoidal pituitary surgery for a GH-secreting pituitary adenoma. She presented with headaches and decreased visual acuity, and showed unsuppressed GH in an oral glucose load test with high IGF-1 levels. Brain MRI showed a suprasellar cystic mass and the patient underwent surgery for cyst drainage resulting in postoperative improvement in her vision. Biopsy of the mass confirmed the diagnosis of a craniopharyngioma. We stress the need for close follow-up of patients with acromegaly with adequate control of GH and IGF-1 levels

Bilateral renal angiomyolipoma with bilateral sarcomatous change

A 54-year-old man presented to the nephrology clinic with three months history of hematuria, weight loss and loss of appetite. Radiological and pathological investigations pointed to the diagnosis of multiple bilateral renal angiomyolipomas with bilateral high grade sarcomatuos transformation and lung metastasis, and with no manifestations of tuberous sclerosis. This is the first reported case of bilateral renal angiomyolipomas with multiple sarcomatous changes